Phospholipase A1 member A (EC 3.1.1.111) (Phosphatidylserine-specific phospholipase A1) (PS-PLA1)
1_MPPGP 6_ WESCF 11_ WVGGL 16_ ILWLS 21_ VGSSG 26_ DAPPT 31_ PQPKC 36_ ADFQS 41_ ANLFE 46_ GTDLK 51_ VQFLL 56_ FVPSN 61_ PSCGQ 66_ LVEGS 71_ SDLQN 76_ SGFNA 81_ TLGTK 86_ LIIHG 91_ FRVLG 96_ TKPSW 101_ IDTFI 106_ RTLLR 111_ ATNAN 116_ VIAVD 121_ WIYGS 126_ TGVYF 131_ SAVKN 136_ VIKLS 141_ LEISL 146_ FLNKL 151_ LVLGV 156_ SESSI 161_ HIIGV 166_ SLGAH 171_ VGGMV 176_ GQLFG 181_ GQLGQ 186_ ITGLD 191_ PAGPE 196_ YTRAS 201_ VEERL 206_ DAGDA 211_ LFVEA 216_ IHTDT 221_ DNLGI 226_ RIPVG 231_ HVDYF 236_ VNGGQ 241_ DQPGC 246_ PTFFY 251_ AGYSY 256_ LICDH 261_ MRAVH 266_ LYISA 271_ LENSC 276_ PLMAF 281_ PCASY 286_ KAFLA 291_ GRCLD 296_ CFNPF 301_ LLSCP 306_ RIGLV 311_ EQGGV 316_ KIEPL 321_ PKEVK 326_ VYLLT 331_ TSSAP 336_ YCMHH 341_ SLVEF 346_ HLKEL 351_ RNKDT 356_ NIEVT 361_ FLSSN 366_ ITSSS 371_ KITIP 376_ KQQRY 381_ GKGII 386_ AHATP 391_ QCQIN 396_ QVKFK 401_ FQSSN 406_ RVWKK 411_ DRTTI 416_ IGKFC 421_ TALLP 426_ VNDRE 431_ KMVCL 436_ PEPVN 441_ LQASV 446_ TVSCD 451_LKIAC
1: Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity)
2: Hydrolyzes lyso-PS but not PS