Akirin-2
1_MACGA 6_ TLKRT 11_ LDFDP 16_ LLSPA 21_ SPKRR 26_ RCAPL 31_ SAPTS 36_ AAASP 41_ LSAAA 46_ ATAAS 51_ FSAAA 56_ ASPQK 61_ YLRME 66_ PSPFG 71_ DVSSR 76_ LTTEQ 81_ ILYNI 86_ KQEYK 91_ RMQKR 96_ RHLET 101_ SFQQT 106_ DPCCT 111_ SDAQP 116_ HAFLL 121_ SGPAS 126_ PGTSS 131_ AASSP 136_ LKKEQ 141_ PLFTL 146_ RQVGM 151_ ICERL 156_ LKERE 161_ EKVRE 166_ EYEEI 171_ LNTKL 176_ AEQYD 181_ AFVKF 186_ THDQI 191_ MRRYG 196_EQPAS
1: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity)