EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein)
1_MEDDA 6_ PVIYG 11_ LEFQA 16_ RALTP 21_ QTAET 26_ DAIRF 31_ LVGTQ 36_ SLKYD 41_ NQIHI 46_ IDFDD 51_ ENNII 56_ NKNVL 61_ LHQAG 66_ EIWHI 71_ SASPA 76_ DRGVL 81_ TTCYN 86_ RTSDS 91_ KVLTC 96_ AAVWR 101_ MPKEL 106_ ESGSH 111_ ESPDD 116_ SSSTA 121_ QTLEL 126_ LCHLD 131_ NTAHG 136_ NMACV 141_ VWEPM 146_ GDGKK 151_ IISLA 156_ DNHIL 161_ LWDLQ 166_ ESSSQ 171_ AVLAS 176_ SASLE 181_ GKGQL 186_ KFTSG 191_ RWSPH 196_ HNCTQ 201_ VATAN 206_ DTTLR 211_ GWDTR 216_ SMSQI 221_ YCIEN 226_ AHGQL 231_ VRDLD 236_ FNPNK 241_ QYYLA 246_ SCGDD 251_ CKVKF 256_ WDTRN 261_ VTEPV 266_ KTLEE 271_ HSHWV 276_ WNVRY 281_ NHSHD 286_ QLVLT 291_ GSSDS 296_ RVILS 301_ NMVSI 306_ SSEPF 311_ GHLVD 316_ DDDIS 321_ DQEDH 326_ RSEEK 331_ SKEPL 336_ QDNVI 341_ ATYEE 346_ HEDSV 351_ YAVDW 356_ SSADP 361_ WLFAS 366_ LSYDG 371_ RLVIN 376_ RVPRA 381_LKYHI
1: Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity)