Transmembrane 4 L6 family member 20
1_MTCCE 6_ GWTSC 11_ NGFSL 16_ LVLLL 21_ LGVVL 26_ NAIPL 31_ IVSLV 36_ EEDQF 41_ SQNPI 46_ SCFEW 51_ WFPGI 56_ IGAGL 61_ MAIPA 66_ TTMSL 71_ TARKR 76_ ACCNN 81_ RTGMF 86_ LSSLF 91_ SVITV 96_ IGALY 101_ CMLIS 106_ IQALL 111_ KGPLM 116_ CNSPS 121_ NSNAN 126_ CEFSL 131_ KNISD 136_ IHPES 141_ FNLQW 146_ FFNDS 151_ CAPPT 156_ GFNKP 161_ TSNDT 166_ MASGW 171_ RASSF 176_ HFDSE 181_ ENKHR 186_ LIHFS 191_ VFLGL 196_ LLVGI 201_ LEVLF 206_ GLSQI 211_ VIGFL 216_ GCLCG 221_VSKRR
1: Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293)