WD repeat-containing protein 81
1_MAQGS 6_ GGREG 11_ ALRTP 16_ AGGWH 21_ SPPSP 26_ DMQEL 31_ LRSVE 36_ RDLSI 41_ DPRQL 46_ APAPG 51_ GTHVV 56_ ALVPA 61_ RWLAS 66_ LRDRR 71_ LPLGP 76_ CPRAE 81_ GLGEA 86_ EVRTL 91_ LQRSV 96_ QRLPA 101_ GWTRV 106_ EVHGL 111_ RKRRL 116_ SYPLG 121_ GGLPF 126_ EDGSC 131_ GPETL 136_ TRFMQ 141_ EVAAQ 146_ NYRNL 151_ WRHAY 156_ HTYGQ 161_ PYSHS 166_ PAPSA 171_ VPALD 176_ SVRQA 181_ LQRVY 186_ GCSFL 191_ PVGET 196_ TQCPS 201_ YAREG 206_ PCPPR 211_ GSPAC 216_ PSLLR 221_ AEALL 226_ ESPEM 231_ LYVVH 236_ PYVQF 241_ SLHDV 246_ VTFSP 251_ AKLTN 256_ SQAKV 261_ LFILF 266_ RVLRA 271_ MDACH 276_ RQGLA 281_ CGALS 286_ LYHIA 291_ VDEKL 296_ CSELR 301_ LDLSA 306_ YERPE 311_ EDENE 316_ EAPVA 321_ RDEAG 326_ IVSQE 331_ EQGGQ 336_ PGQPT 341_ GQEEL 346_ RSLVL 351_ DWVHG 356_ RISNF 361_ HYLMQ 366_ LNRLA 371_ GRRQG 376_ DPNYH 381_ PVLPW 386_ VVDFT 391_ TPHGR 396_ FRDLR 401_ KSKFR 406_ LNKGD 411_ KQLDF 416_ TYEMT 421_ RQAFV 426_ AGGAG 431_ GGEPP 436_ HVPHH 441_ ISDVL 446_ SDITY 451_ YVYKA 456_ RRTPR 461_ SVLCG 466_ HVRAQ 471_ WEPHE 476_ YPASM 481_ ERMQN 486_ WTPDE 491_ CIPEF 496_ YTDPS 501_ IFRSI 506_ HPDMP 511_ DLDVP 516_ AWCSS 521_ SQEFV 526_ AAHRA 531_ LLESR 536_ EVSRD 541_ LHHWI 546_ DLTFG 551_ YKLQG 556_ KEAVK 561_ EKNVC 566_ LHLVD 571_ AHTHL 576_ ASYGV 581_ VQLFD 586_ QPHPQ 591_ RLAGA 596_ PALAP 601_ EPPLI 606_ PKLLV 611_ QTIQE 616_ TTGRE 621_ DFTEN 626_ PGQLP 631_ NGVGR 636_ PVLEA 641_ TPCEA 646_ SWTRD 651_ RPVAG 656_ EDDLE 661_ QATEA 666_ LDSIS 671_ LAGKA 676_ GDQLG 681_ SSSQA 686_ SPGLL 691_ SFSVA 696_ SASRP 701_ GRRNK 706_ AAGAD 711_ PGEGE 716_ EGRIL 721_ LPEGF 726_ NPMQA 731_ LEELE 736_ KTGNF 741_ LAKGL 746_ GGLLE 751_ VPEQP 756_ RVQPA 761_ VPLQC 766_ LLHRD 771_ MQALG 776_ VLLAE 781_ MVFAT 786_ RVRTL 791_ QPDAP 796_ LWVRF 801_ QAVRG 806_ LCTRH 811_ PKEVP 816_ VSLQP 821_ VLDTL 826_ LQMSG 831_ PEVPM 836_ GAERG 841_ KLDQL 846_ FEYRP 851_ VSQGL 856_ PPPCP 861_ SQLLS 866_ PFSSV 871_ VPFPP 876_ YFPAL 881_ HRFIL 886_ LYQAR 891_ RVEDE 896_ AQGRE 901_ LVFAL 906_ WQQLG 911_ AVLKD 916_ ITPEG 921_ LEILL 926_ PFVLS 931_ LMSEE 936_ HTAVY 941_ TAWYL 946_ FEPVA 951_ KALGP 956_ KNANK 961_ YLLKP 966_ LIGAY 971_ ESPCQ 976_ LHGRF 981_ YLYTD 986_ CFVAQ 991_ LMVRL 996_ GLQAF 1001_ LTHLL 1006_ PHVLQ 1011_ VLAGA 1016_ EASQE 1021_ ESKDL 1026_ AGAAE 1031_ EEESG 1036_ LPGAG 1041_ PGSCA 1046_ FGEEI 1051_ PMDGE 1056_ PPASS 1061_ GLGLP 1066_ DYTSG 1071_ VSFHD 1076_ QADLP 1081_ ETEDF 1086_ QAGLY 1091_ VTESP 1096_ QPQEA 1101_ EAVSL 1106_ GRLSD 1111_ KSSTS 1116_ ETSLG 1121_ EERAP 1126_ DEGGA 1131_ PVDKS 1136_ SLRSG 1141_ DSSQD 1146_ LKQSE 1151_ GSEEE 1156_ EEEED 1161_ SCVVL 1166_ EEEEG 1171_ EQEEV 1176_ TGASE 1181_ LTLSD 1186_ TVLSM 1191_ ETVVA 1196_ GGSGG 1201_ DGEEE 1206_ EEALP 1211_ EQSEG 1216_ KEQKI 1221_ LLDTA 1226_ CKMVR 1231_ WLSAK 1236_ LGPTV 1241_ ASRHV 1246_ ARNLL 1251_ RLLTS 1256_ CYVGP 1261_ TRQQF 1266_ TVSSG 1271_ ESPPL 1276_ SAGNI 1281_ YQKRP 1286_ VLGDI 1291_ VSGPV 1296_ LSCLL 1301_ HIARL 1306_ YGEPV 1311_ LTYQY 1316_ LPYIS 1321_ YLVAP 1326_ GSASG 1331_ PSRLN 1336_ SRKEA 1341_ GLLAA 1346_ VTLTQ 1351_ KIIVY 1356_ LSDTT 1361_ LMDIL 1366_ PRISH 1371_ EVLLP 1376_ VLSFL 1381_ TSLVT 1386_ GFPSG 1391_ AQART 1396_ ILCVK 1401_ TISLI 1406_ ALICL 1411_ RIGQE 1416_ MVQQH 1421_ LSEPV 1426_ ATFFQ 1431_ VFSQL 1436_ HELRQ 1441_ QDLKL 1446_ DPAGR 1451_ GEGQL 1456_ PQVVF 1461_ SDGQQ 1466_ RPVDP 1471_ ALLDE 1476_ LQKVF 1481_ TLEMA 1486_ YTIYV 1491_ PFSCL 1496_ LGDII 1501_ RKIIP 1506_ NHELV 1511_ GELAA 1516_ LYLES 1521_ ISPSS 1526_ RNPAS 1531_ VEPTM 1536_ PGTGP 1541_ EWDPH 1546_ GGGCP 1551_ QDDGH 1556_ SGTFG 1561_ SVLVG 1566_ NRIQI 1571_ PNDSR 1576_ PENPG 1581_ PLGPI 1586_ SGVGG 1591_ GGLGS 1596_ GSDDN 1601_ ALKQE 1606_ LPRSV 1611_ HGLSG 1616_ NWLAY 1621_ WQYEI 1626_ GVSQQ 1631_ DAHFH 1636_ FHQIR 1641_ LQSFP 1646_ GHSGA 1651_ VKCVA 1656_ PLSSE 1661_ DFFLS 1666_ GSKDR 1671_ TVRLW 1676_ PLYNY 1681_ GDGTS 1686_ ETAPR 1691_ LVYTQ 1696_ HRKSV 1701_ FFVGQ 1706_ LEAPQ 1711_ HVVSC 1716_ DGAVH 1721_ VWDPF 1726_ TGKTL 1731_ RTVEP 1736_ LDSRV 1741_ PLTAV 1746_ AVMPA 1751_ PHTSI 1756_ TMASS 1761_ DSTLR 1766_ FVDCR 1771_ KPGLQ 1776_ HEFRL 1781_ GGGLN 1786_ PGLVR 1791_ ALAIS 1796_ PSGRS 1801_ VVAGF 1806_ SSGFM 1811_ VLLDT 1816_ RTGLV 1821_ LRGWP 1826_ AHEGD 1831_ ILQIK 1836_ AVEGS 1841_ VLVSS 1846_ SSDHS 1851_ LTVWK 1856_ ELEQK 1861_ PTHHY 1866_ KSASD 1871_ PIHTF 1876_ DLYGS 1881_ EVVTG 1886_ TVSNK 1891_ IGVCS 1896_ LLEPP 1901_ SQATT 1906_ KLSSE 1911_ NFRGT 1916_ LTSLA 1921_ LLPTK 1926_ RHLLL 1931_ GSDNG 1936_VIRLL
1: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity)