Coiled-coil domain-containing protein 93
1_MGLPR 6_ GPEGQ 11_ GLPEV 16_ ETRED 21_ EEQNV 26_ KLTEI 31_ LELLV 36_ AAGYF 41_ RARIK 46_ GLSPF 51_ DKVVG 56_ GMTWC 61_ ITTCN 66_ FDVDV 71_ DLLFQ 76_ ENSTI 81_ GQKIA 86_ LSEKI 91_ VSVLP 96_ RMKCP 101_ HQLEP 106_ HQIQG 111_ MDFIH 116_ IFPVV 121_ QWLVK 126_ RAIET 131_ KEEMG 136_ DYIRS 141_ YSVSQ 146_ FQKTY 151_ SLPED 156_ DDFIK 161_ RKEKA 166_ IKTVV 171_ DLSEV 176_ YKPRR 181_ KYKRH 186_ QGAEE 191_ LLDEE 196_ SRIHA 201_ TLLEY 206_ GRRYG 211_ FSRQS 216_ KMEKA 221_ EDKKT 226_ ALPAG 231_ LSATE 236_ KADAH 241_ EEDEL 246_ RAAEE 251_ QRIQS 256_ LMTKM 261_ TAMAN 266_ EESRL 271_ TASSV 276_ GQIVG 281_ LCSAE 286_ IKQIV 291_ SEYAE 296_ KQSEL 301_ SAEES 306_ PEKLG 311_ TSQLH 316_ RRKVI 321_ SLNKQ 326_ IAQKT 331_ KHLEE 336_ LRASH 341_ TSLQA 346_ RYNEA 351_ KKTLT 356_ ELKTY 361_ SEKLD 366_ KEQAA 371_ LEKIE 376_ SKADP 381_ SILQN 386_ LRALV 391_ AMNEN 396_ LKSQE 401_ QEFKA 406_ HCREE 411_ MTRLQ 416_ QEIEN 421_ LKAER 426_ APRGD 431_ EKTLS 436_ SGEPP 441_ GTLTS 446_ AMTHD 451_ EDLDR 456_ RYNME 461_ KEKLY 466_ KIRLL 471_ QARRN 476_ REIAI 481_ LHRKI 486_ DEVPS 491_ RAELI 496_ QYQKR 501_ FIELY 506_ RQISA 511_ VHKET 516_ KQFFT 521_ LYNTL 526_ DDKKV 531_ YLEKE 536_ ISLLN 541_ SIHEN 546_ FSQAM 551_ ASPAA 556_ RDQFL 561_ RQMEQ 566_ IVEGI 571_ KQSRM 576_ KMEKK 581_ KQENK 586_ MRRDQ 591_ LNDQY 596_ LELLE 601_ KQRLY 606_ FKTVK 611_ EFKEE 616_ GRKNE 621_ MLLSK 626_VKAKA
1: Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947)
2: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface