Gene name: SPIN4

Uniprot entry:

Q56A73

Protein names:

Spindlin-4

Protein sequence:

1_MSPPT 6_ VPPMG 11_ VDGVS 16_ AYLMK 21_ KRHTH 26_ RKQRR 31_ KPTFL 36_ TRRNI 41_ VGCRI 46_ QHGWK 51_ EGNEP 56_ VEQWK 61_ GTVLE 66_ QVSVK 71_ PTLYI 76_ IKYDG 81_ KDSVY 86_ GLELH 91_ RDKRV 96_ LALEI 101_ LPERV 106_ PTPRI 111_ DSRLA 116_ DSLIG 121_ KAVEH 126_ VFEGE 131_ HGTKD 136_ EWKGM 141_ VLARA 146_ PVMDT 151_ WFYIT 156_ YEKDP 161_ VLYMY 166_ TLLDD 171_ YKDGD 176_ LRIIP 181_ DSNYY 186_ FPTAE 191_ QEPGE 196_ VVDSL 201_ VGKQV 206_ EHAKD 211_ DGSKR 216_ TGIFI 221_ HQVVA 226_ KPSVY 231_ FIKFD 236_ DDIHI 241_YVYGL

Protein annotations

Protein functions:

1: Binds to acetylated and methylated histones, including H3K4me3 and H4K20me3, probably acting as a histone reader that recognizes chromatin marks and mediates downstream cellular effects (PubMed:29061846, PubMed:36927955). Promotes canonical WNT signaling, and is involved in the down-regulation of cell proliferation (PubMed:36927955)