Gene name: PYDC2

Uniprot entry:

Q56P42

Protein names:

Pyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2)

Protein sequence:

1_MASSA 6_ ELDFN 11_ LQALL 16_ EQLSQ 21_ DELSK 26_ FKSLI 31_ RTISL 36_ GKELQ 41_ TVPQT 46_ EVDKA 51_ NGKQL 56_ VEIFT 61_ SHSCS 66_ YWAGM 71_ AAIQV 76_ FEKMN 81_ QTHLS 86_ GRADE 91_HCVMP

Protein annotations

Protein functions:

1: May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17178784, PubMed:17339483). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464)