KH domain-containing protein 3 (ES cell-associated transcript 1 protein) (KHDC3-like protein)
1_MDAPR 6_ RFPTL 11_ VQLMQ 16_ PKAMP 21_ VEVLG 26_ HLPKR 31_ FSWFH 36_ SEFLK 41_ NPKVV 46_ RLEVW 51_ LVEKI 56_ FGRGG 61_ ERIPH 66_ VQGMS 71_ QILIH 76_ VNRLD 81_ PNGEA 86_ EILVF 91_ GRPSY 96_ QEDTI 101_ KMIMN 106_ LADYH 111_ RQLQA 116_ KGSGK 121_ ALAQD 126_ VATQK 131_ AETQR 136_ SSIEV 141_ REAGT 146_ QRSVE 151_ VREAG 156_ TQRSV 161_ EVQEV 166_ GTQGS 171_ PVEVQ 176_ EAGTQ 181_ QSLQA 186_ ANKSG 191_ TQRSP 196_ EAASK 201_ AVTQR 206_ FREDA 211_RDPVT
1: Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (By similarity). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (By similarity). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (By similarity). KHDC3 ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation (PubMed:31609975). Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (By similarity). Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks (By similarity). Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (By similarity). May regulate normal development of learning, memory and anxiety (By similarity). Capable of binding RNA (By similarity)