Transmembrane protein 41B (Protein stasimon)
1_MAKGR 6_ VAERS 11_ QLGAH 16_ HTTPV 21_ GDGAA 26_ GTRGL 31_ AAPGS 36_ RDHQK 41_ EKSWV 46_ EAGSA 51_ RMSLL 56_ ILVSI 61_ FLSAA 66_ FVMFL 71_ VYKNF 76_ PQLSE 81_ EERVN 86_ MKVPR 91_ DMDDA 96_ KALGK 101_ VLSKY 106_ KDTFY 111_ VQVLV 116_ AYFAT 121_ YIFLQ 126_ TFAIP 131_ GSIFL 136_ SILSG 141_ FLYPF 146_ PLALF 151_ LVCLC 156_ SGLGA 161_ SFCYM 166_ LSYLV 171_ GRPVV 176_ YKYLT 181_ EKAVK 186_ WSQQV 191_ ERHRE 196_ HLINY 201_ IIFLR 206_ ITPFL 211_ PNWFI 216_ NITSP 221_ VINVP 226_ LKVFF 231_ IGTFL 236_ GVAPP 241_ SFVAI 246_ KAGTT 251_ LYQLT 256_ TAGEA 261_ VSWNS 266_ IFILM 271_ ILAVL 276_ SILPA 281_ IFQKK 286_LKQKF
1: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:33850023, PubMed:33929485, PubMed:34015269). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:33850023, PubMed:33929485, PubMed:34015269). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:30093494, PubMed:30126924, PubMed:30933966, PubMed:33850023, PubMed:33929485, PubMed:34015269, PubMed:34043740). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:33850023). Required for normal motor neuron development (By similarity)
2: (Microbial infection) Critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus (PubMed:33338421, PubMed:33382968). Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles (PubMed:33382968)