UMP-CMP kinase 2, mitochondrial (EC 2.7.4.14) (Nucleoside-diphosphate kinase) (EC 2.7.4.6)
1_MAFAR 6_ RLLRG 11_ PLSGP 16_ LLGRR 21_ GVCAG 26_ AMAPP 31_ RRFVL 36_ ELPDC 41_ TLAHF 46_ ALGAD 51_ APGDA 56_ DAPDP 61_ RLAAL 66_ LGPPE 71_ RSYSL 76_ CVPVT 81_ PDAGC 86_ GARVR 91_ AARLH 96_ QRLLH 101_ QLRRG 106_ PFQRC 111_ QLLRL 116_ LCYCP 121_ GGQAG 126_ GAQQG 131_ FLLRD 136_ PLDDP 141_ DTRQA 146_ LLELL 151_ GACQE 156_ APRPH 161_ LGEFE 166_ ADPRG 171_ QLWQR 176_ LWEVQ 181_ DGRRL 186_ QVGCA 191_ QVVPV 196_ PEPPL 201_ HPVVP 206_ DLPSS 211_ VVFPD 216_ REAAR 221_ AVLEE 226_ CTSFI 231_ PEARA 236_ VLDLV 241_ DQCPK 246_ QIQKG 251_ KFQVV 256_ AIEGL 261_ DATGK 266_ TTVTQ 271_ SVADS 276_ LKAVL 281_ LKSPP 286_ SCIGQ 291_ WRKIF 296_ DDEPT 301_ IIRRA 306_ FYSLG 311_ NYIVA 316_ SEIAK 321_ ESAKS 326_ PVIVD 331_ RYWHS 336_ TATYA 341_ IATEV 346_ SGGLQ 351_ HLPPA 356_ HHPVY 361_ QWPED 366_ LLKPD 371_ LILLL 376_ TVSPE 381_ ERLQR 386_ LQGRG 391_ MEKTR 396_ EEAEL 401_ EANSV 406_ FRQKV 411_ EMSYQ 416_ RMENP 421_ GCHVV 426_ DASPS 431_ REKVL 436_ QTVLS 441_LIQNS
1: Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways (PubMed:17999954, PubMed:30083606, PubMed:36930652, PubMed:37075076). Restricts the replication of multiple viruses including flaviviruses or coronaviruses (PubMed:30083606, PubMed:36930652, PubMed:37075076). Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (PubMed:36930652). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (PubMed:37075076). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (By similarity). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (By similarity). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (By similarity)