Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)
1_MALST 6_ IVSQR 11_ KQIKR 16_ KAPRG 21_ FLKRV 26_ FKRKK 31_ PQLRL 36_ EKSGD 41_ LLVHL 46_ NCLLF 51_ VHRLA 56_ EESRT 61_ NACAS 66_ KCRVI 71_ NKEHV 76_ LAAAK 81_VILKK
1: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis