Caspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 beta converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme)
1_MADKV 6_ LKEKR 11_ KLFIH 16_ SMGEG 21_ TINGL 26_ LDELL 31_ QTRVL 36_ NQEEM 41_ EKVKR 46_ ENATV 51_ MDKTR 56_ ALIDS 61_ VIPKG 66_ AQACQ 71_ ICITY 76_ ICEED 81_ SYLAE 86_ TLGLS 91_ AALQA 96_ VQDNP 101_ AMPTC 106_ SSPEG 111_ RIKLC 116_ FLEDA 121_ QRIWK 126_ QKLQR 131_ CHVQN 136_ TIIKW 141_ SERYT 146_ SGSFE 151_ MQWLF 156_ LRTNF 161_ IERFW 166_ RNILL 171_ LPLHK 176_ GSLYP 181_ RIPGL 186_ GKELQ 191_TGTHK
1: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2