Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1)
1_MAKER 6_ CLKKS 11_ FQDSL 16_ EDIKK 21_ RMKEK 26_ RNKNL 31_ AEIGK 36_ RRSFI 41_ AAPCQ 46_ IITNT 51_ STLLK 56_ NYQDN 61_ NKMLV 66_ LALEN 71_ EKSKV 76_ KEAQD 81_ IILQL 86_ RKECY 91_ YLTCQ 96_ LYALK 101_ GKLTS 106_ QQTVE 111_ PAQNQ 116_ EICSS 121_ GMDPN 126_ SDDSS 131_ RNLFV 136_ KDLPQ 141_ IPLEE 146_ TELPG 151_ QGESF 156_ QIEDQ 161_ IPTIP 166_ QDTLG 171_ VDFDS 176_ GEAKS 181_ TDNVL 186_ PRTVS 191_ VRSSL 196_ KKHCN 201_ SICQF 206_ DSLDD 211_ FETSH 216_ LAGKS 221_ FEFER 226_ VGFLD 231_ PLVNM 236_ HIPEN 241_ VQHNA 246_ CQWSK 251_ DQVNL 256_ SPKLI 261_ QPGTF 266_ TKTKE 271_ DILES 276_ KSEQT 281_ KSKQR 286_ DTQER 291_ KREEK 296_ RKANR 301_ RKSKR 306_ MSKYK 311_ ENKSE 316_ NKKTV 321_ PQKKM 326_ HKSVS 331_ SNDAY 336_ NFNLE 341_ EGVHL 346_ TPFRQ 351_ KVSND 356_ SNREE 361_ NNESE 366_ VSLCE 371_ SSGSG 376_ DDSDD 381_ LYLPT 386_ CKYIQ 391_ NPTSN 396_ SDRPV 401_ TRPLA 406_ KRALK 411_ YTDEK 416_ ETEGS 421_ KPTKT 426_ PTTTP 431_ PETQQ 436_ SPHLS 441_ LKDIT 446_ NVSLY 451_ PVVKI 456_ RRLSL 461_ SPKKN 466_ KASPA 471_ VALPK 476_ RRCTA 481_ SVNYK 486_ EPTLA 491_ SKLRR 496_ GDPFT 501_ DLCFL 506_ NSPIF 511_ KQKKD 516_ LRRSK 521_ KRALE 526_ VSPAK 531_ EAIFI 536_ LYYVR 541_ EFVSR 546_ FPDCR 551_ KCKLE 556_THICL
1: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase