DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)]
1_MPRVH 6_ NIKKS 11_ LTPHI 16_ SCVTN 21_ ESDNL 26_ LDFLP 31_ DRLRA 36_ KLLPF 41_ QKDGI 46_ IFALK 51_ RNGRC 56_ MVADE 61_ MGLGK 66_ TIQAI 71_ GITYF 76_ YKEEW 81_ PLLIV 86_ VPSSL 91_ RYPWT 96_ EEIEK 101_ WIPEL 106_ SPEEI 111_ NVIQN 116_ KTDVR 121_ RMSTS 126_ KVTVL 131_ GYGLL 136_ TADAK 141_ TLIDA 146_ LNNQN 151_ FKVVI 156_ VDESH 161_ YMKSR 166_ NATRS 171_ RILLP 176_ IVQKA 181_ RRAIL 186_ LTGTP 191_ ALGRP 196_ EELFM 201_ QIEAL 206_ FPQKF 211_ GRWTD 216_ YAKRY 221_ CNAHI 226_ RYFGK 231_ RPQWD 236_ CRGAS 241_ NLNEL 246_ HQLLS 251_ DIMIR 256_ RLKTE 261_ VLTQL 266_ PPKVR 271_ QRIPF 276_ DLPSA 281_ AAKEL 286_ NTSFE 291_ EWEKI 296_ MRTPN 301_ SGAME 306_ TVMGL 311_ ITRMF 316_ KQTAI 321_ AKAGA 326_ VKDYI 331_ KMMLQ 336_ NDSLK 341_ FLVFA 346_ HHLSM 351_ LQACT 356_ EAVIE 361_ NKTRY 366_ IRIDG 371_ SVSSS 376_ ERIHL 381_ VNQFQ 386_ KDPDT 391_ RVAIL 396_ SIQAA 401_ GQGLT 406_ FTAAS 411_ HVVFA 416_ ELYWD 421_ PGHIK 426_ QAEDR 431_ AHRIG 436_ QCSSV 441_ NIHYL 446_ IANGT 451_ LDTLM 456_ WGMLN 461_ RKAQV 466_ TGSTL 471_ NGRKE 476_ KIQAE 481_ EGDKE 486_ KWDFL 491_ QFAEA 496_ WTPND 501_ SSEEL 506_ RKEAL 511_ FTHFE 516_ KEKQH 521_ DIRSF 526_ FVPQP 531_ KKRQL 536_ MTSCD 541_ ESKRF 546_ REENT 551_ VVSSD 556_ PTKTA 561_ ARDII 566_ DYESD 571_ VEPET 576_ KRLKL 581_ AASED 586_ HCSPS 591_ EETPS 596_ QSKQI 601_ RTPLV 606_ ESVQE 611_ AKAQL 616_ TTPAF 621_ PVEGW 626_ QCSLC 631_ TYINN 636_ SELPY 641_ CEMCE 646_ TPQGS 651_ AVMQI 656_ DSLNH 661_ IQDKN 666_ EKDDS 671_ QKDTS 676_ KKVQT 681_ ISDCE 686_ KQALA 691_ QSEPG 696_ QLADS 701_ KEETP 706_ KIEKE 711_ DGLTS 716_ QPGNE 721_ QWKSS 726_ DTLPV 731_ YDTLM 736_ FCASR 741_ NTDRI 746_ HIYTK 751_ DGKQM 756_ SCNFI 761_ PLDIK 766_ LDLWE 771_ DLPAS 776_ FQLKQ 781_ YRSLI 786_ LRFVR 791_ EWSSL 796_ TAMKQ 801_ RIIRK 806_ SGQLF 811_ CSPIL 816_ ALEEI 821_ TKQQT 826_ KQNCT 831_ KRYIT 836_ KEDVA 841_ VASMD 846_ KVKNV 851_ GGHVR 856_ LITKE 861_ SRPRD 866_ PFTKK 871_ LLEDG 876_ ACVPF 881_ LNPYT 886_ VQADL 891_ TVKPS 896_ TSKGY 901_ LQAVD 906_ NEGNP 911_ LCLRC 916_ QQPTC 921_ QTKQA 926_ CKANS 931_ WDSRF 936_ CSLKC 941_ QEEFW 946_ IRSNN 951_ SYLRA 956_ KVFET 961_ EHGVC 966_ QLCNV 971_ NAQEL 976_ FLRLR 981_ DAPKS 986_ QRKNL 991_ LYATW 996_ TSKLP 1001_ LEQLN 1006_ EMIRN 1011_ PGEGH 1016_ FWQVD 1021_ HIKPV 1026_ YGGGG 1031_ QCSLD 1036_ NLQTL 1041_ CTVCH 1046_ KERTA 1051_ RQAKE 1056_ RSQVR 1061_ RQSLA 1066_ SKHGS 1071_DITRF
1: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22704558, PubMed:22705370)