Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)
1_MGKPR 6_ QNPST 11_ LVSTL 16_ CEAEP 21_ KGKLW 26_ VNGYA 31_ GTQGT 36_ RDATL 41_ QTRLI 46_ PLSFH 51_ LQRGK 56_ GLAAP 61_ LSALS 66_ APRLP 71_ ERPAD 76_ GRVAV 81_ DAQPA 86_ ARSMD 91_ SDSGE 96_ QSEGE 101_ PVTAA 106_ GPDVF 111_ SSKSL 116_ ALQAQ 121_ KKILS 126_ KIASK 131_ TVANM 136_ LIDDT 141_ SSEIF 146_ DELYK 151_ VTKEH 156_ THNKK 161_ EAHKI 166_ MKDLI 171_ KVAIK 176_ IGILY 181_ RNNQF 186_ SQEEL 191_ VIVEK 196_ FRKKL 201_ NQTAM 206_ TIVSF 211_ YEVEY 216_ TFDRN 221_ VLSNL 226_ LHECK 231_ DLVHE 236_ LVQRH 241_ LTPRT 246_ HGRIN 251_ HVFNH 256_ FADVE 261_ FLSTL 266_ YSLDG 271_ DCRPN 276_ LKRIC 281_ EGINK 286_LLDEK
1: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling