Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4)
1_MLCWG 6_ NASFG 11_ QLGLG 16_ GIDEE 21_ IVLEP 26_ RKSDF 31_ FINKR 36_ VRDVG 41_ CGLRH 46_ TVFVL 51_ DDGTV 56_ YTCGC 61_ NDLGQ 66_ LGHEK 71_ SRKKP 76_ EQVVA 81_ LDAQN 86_ IVAVS 91_ CGEAH 96_ TLALN 101_ DKGQV 106_ YAWGL 111_ DSDGQ 116_ LGLVG 121_ SEECI 126_ RVPRN 131_ IKSLS 136_ DIQIV 141_ QVACG 146_ YYHSL 151_ ALSKA 156_ SEVFC 161_ WGQNK 166_ YGQLG 171_ LGTDC 176_ KKQTS 181_ PQLLK 186_ SLLGI 191_ PFMQV 196_ AAGGA 201_ HSFVL 206_ TLSGA 211_ IFGWG 216_ RNKFG 221_ QLGLN 226_ DENDR 231_ YVPNL 236_ LKSLR 241_ SQKIV 246_ YICCG 251_ EDHTA 256_ ALTKE 261_ GGVFT 266_ FGAGG 271_ YGQLG 276_ HNSTS 281_ HEINP 286_ RKVFE 291_ LMGSI 296_ VTEIA 301_ CGRQH 306_ TSAFV 311_ PSSGR 316_ IYSFG 321_ LGGNG 326_ QLGTG 331_ STSNR 336_ KSPFT 341_ VKGNW 346_ YPYNG 351_ QCLPD 356_ IDSEE 361_ YFCVK 366_ RIFSG 371_ GDQSF 376_ SHYSS 381_ PQNCG 386_ PPDDF 391_ RCPNP 396_ TKQIW 401_ TVNEA 406_ LIQKW 411_ LSYPS 416_ GRFPV 421_ EIANE 426_ IDGTF 431_ SSSGC 436_ LNGSF 441_ LAVSN 446_ DDHYR 451_ TGTRF 456_ SGVDM 461_ NAARL 466_ LFHKL 471_ IQPDH 476_ PQISQ 481_ QVAAS 486_ LEKNL 491_ IPKLT 496_ SSLPD 501_ VEALR 506_ FYLTL 511_ PECPL 516_ MSDSN 521_ NFTTI 526_ AIPFG 531_ TALVN 536_ LEKAP 541_ LKVLE 546_ NWWSV 551_ LEPPL 556_ FLKIV 561_ ELFKE 566_ VVVHL 571_ LKLYK 576_ IGIPP 581_ SERRI 586_ FNSFL 591_ HTALK 596_ VLEIL 601_ HRVNE 606_ KMGQI 611_ IQYDK 616_ FYIHE 621_ VQELI 626_ DIRND 631_ YINWV 636_ QQQAY 641_ GMDVN 646_ HGLTE 651_ LADIP 656_ VTICT 661_ YPFVF 666_ DAQAK 671_ TTLLQ 676_ TDAVL 681_ QMQMA 686_ IDQAH 691_ RQNVS 696_ SLFLP 701_ VIESV 706_ NPCLI 711_ LVVRR 716_ ENIVG 721_ DAMEV 726_ LRKTK 731_ NIDYK 736_ KPLKV 741_ IFVGE 746_ DAVDA 751_ GGVRK 756_ EFFLL 761_ IMREL 766_ LDPKY 771_ GMFRY 776_ YEDSR 781_ LIWFS 786_ DKTFE 791_ DSDLF 796_ HLIGV 801_ ICGLA 806_ IYNCT 811_ IVDLH 816_ FPLAL 821_ YKKLL 826_ KKKPS 831_ LDDLK 836_ ELMPD 841_ VGRSM 846_ QQLLD 851_ YPEDD 856_ IEETF 861_ CLNFT 866_ ITVEN 871_ FGATE 876_ VKELV 881_ LNGAD 886_ TAVNK 891_ QNRQE 896_ FVDAY 901_ VDYIF 906_ NKSVA 911_ SLFDA 916_ FHAGF 921_ HKVCG 926_ GKVLL 931_ LFQPN 936_ ELQAM 941_ VIGNT 946_ NYDWK 951_ ELEKN 956_ TEYKG 961_ EYWAE 966_ HPTIK 971_ IFWEV 976_ FHELP 981_ LEKKK 986_ QFLLF 991_ LTGSD 996_ RIPIL 1001_ GMKSL 1006_ KLVIQ 1011_ STGGG 1016_ EEYLP 1021_ VSHTC 1026_ FNLLD 1031_ LPKYT 1036_ EKETL 1041_ RSKLI 1046_ QAIDH 1051_NEGFS
1: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates