Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67)
1_MATRG 6_ GAGVA 11_ MAVWS 16_ LLSAR 21_ AVTAF 26_ LLLFL 31_ PRFLQ 36_ AQTFS 41_ FPFQQ 46_ PEKCD 51_ NNQYF 56_ DISAL 61_ SCVPC 66_ GANQR 71_ QDARG 76_ TSCVC 81_ LPGFQ 86_ MISNN 91_ GGPAI 96_ ICKKC 101_ PENMK 106_ GVTED 111_ GWNCI 116_ SCPSD 121_ LTAEG 126_ KCHCP 131_ IGHIL 136_ VERDI 141_ NGTLL 146_ SQATC 151_ ELCDG 156_ NENSF 161_ MVVNA 166_ LGDRC 171_ VRCEP 176_ TFVNT 181_ SRSCA 186_ CSEPN 191_ ILTGG 196_ LCFSS 201_ TGNFP 206_ LRRIS 211_ AARYG 216_ EVGMS 221_ LTSEW 226_ FAKYL 231_ QSSAA 236_ ACWVY 241_ ANLTS 246_ CQALG 251_ NMCVM 256_ NMNSY 261_ DFATF 266_ DACGL 271_ FQFIF 276_ ENTAG 281_ LSTVH 286_ SISFW 291_ RQNLP 296_ WLFYG 301_ DQLGL 306_ APQVL 311_ SSTSL 316_ PTNFS 321_ FKGEN 326_ QNTKL 331_ KFVAA 336_ SYDIR 341_ GNFLK 346_ WQTLE 351_ GGVLQ 356_ LCPDT 361_ ETRLN 366_ AAYSF 371_ GTTYQ 376_ QNCEI 381_ PISKI 386_ LIDFP 391_ TPIFY 396_ DVYLE 401_ YTDEN 406_ QHQYI 411_ LAVPV 416_ LNLNL 421_ QHNKI 426_ FVNQD 431_ SNSGK 436_ WLLTR 441_ RIFLV 446_ DAVSG 451_ RENDL 456_ GTQPR 461_ VIRVA 466_ TQISL 471_ SVHLV 476_ PNTIN 481_ GNIYP 486_ PLITI 491_ AYSDI 496_ DIKDA 501_ NSQSV 506_ KVSFS 511_ VTYEM 516_ DHGEA 521_ HVQTD 526_ IALGV 531_ LGGLA 536_ VLASL 541_ LKTAG 546_ WKRRI 551_ GSPMI 556_ DLQTV 561_ VKFLV 566_ YYAGD 571_ LANVF 576_ FIITV 581_ GTGLY 586_ WLIFF 591_ KAQKS 596_ VSVLL 601_ PMPIQ 606_ EERFV 611_ TYVGC 616_ AFALK 621_ ALQFL 626_ HKLIS 631_ QITID 636_ VFFID 641_ WERPK 646_ GKVLK 651_ AVEGE 656_ GGVRS 661_ ATVPV 666_ SIWRT 671_ YFVAN 676_ EWNEI 681_ QTVRK 686_ INSLF 691_ QVLTV 696_ LFFLE 701_ VVGFK 706_ NLALM 711_ DSSSS 716_ LSRNP 721_ PSYIA 726_ PYSCI 731_ LRYAV 736_ SAALW 741_ LAIGI 746_ IQVVF 751_ FAVFY 756_ ERFIE 761_ DKIRQ 766_ FVDLC 771_ SMSNI 776_ SVFLL 781_ SHKCF 786_ GYYIH 791_ GRSVH 796_ GHADT 801_ NMEEM 806_ NMNLK 811_ REAEN 816_ LCSQR 821_ GLVPN 826_ TDGQT 831_ FEIAI 836_ SNQMR 841_ QHYDR 846_ IHETL 851_ IRKNG 856_ PARLL 861_ SSSAS 866_ TFEQS 871_ IKAYH 876_ MMNKF 881_ LGSFI 886_ DHVHK 891_ EMDYF 896_ IKDKL 901_ LLERI 906_ LGMEF 911_ MEPME 916_ KSIFY 921_ NDEGY 926_ SFSSV 931_ LYYGN 936_ EATLL 941_ IFDLL 946_ FFCVV 951_ DLACQ 956_ NFILA 961_ SFLTY 966_ LQQEI 971_ FRYIR 976_ NTVGQ 981_ KNLAS 986_KTLVD
1: Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Is a key regulator of stereociliary bundle orientation (By similarity). Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A (PubMed:26035863). In non-canonical Wnt signaling, it may act as ROR2 coreceptor (By similarity)