Gene name: FAM76B

Uniprot entry:

Q5HYJ3

Protein names:

Protein FAM76B

Protein sequence:

1_MAASA 6_ LYACT 11_ KCTQR 16_ YPFEE 21_ LSQGQ 26_ QLCKE 31_ CRIAH 36_ PIVKC 41_ TYCRS 46_ EFQQE 51_ SKTNT 56_ ICKKC 61_ AQNVK 66_ QFGTP 71_ KPCQY 76_ CNIIA 81_ AFIGT 86_ KCQRC 91_ TNSEK 96_ KYGPP 101_ QTCEQ 106_ CKQQC 111_ AFDRK 116_ EEGRR 121_ KVDGK 126_ LLCWL 131_ CTLSY 136_ KRVLQ 141_ KTKEQ 146_ RKSLG 151_ SSHSN 156_ SSSSS 161_ LTEKD 166_ QHHPK 171_ HHHHH 176_ HHHHH 181_ RHSSS 186_ HHKIS 191_ NLSPE 196_ EEQGL 201_ WKQSH 206_ KSSAT 211_ IQNET 216_ PKKKP 221_ KLESK 226_ PSNGD 231_ SSSIN 236_ QSADS 241_ GGTDN 246_ FVLIS 251_ QLKEE 256_ VMSLK 261_ RLLQQ 266_ RDQTI 271_ LEKDK 276_ KLTEL 281_ KADFQ 286_ YQESN 291_ LRTKM 296_ NSMEK 301_ AHKET 306_ VEQLQ 311_ AKNRE 316_ LLKQV 321_ AALSK 326_ GKKFD 331_KSGSI

Protein annotations

Protein functions:

1: Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm (PubMed:37643469). Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling (PubMed:38421448)