Protein crumbs homolog 2 (Crumbs-like protein 2)
1_MALAR 6_ PGTPD 11_ PQALA 16_ SVLLL 21_ LLWAP 26_ ALSLL 31_ AGTVP 36_ SEPPS 41_ ACASD 46_ PCAPG 51_ TECQA 56_ TESGG 61_ YTCGP 66_ MEPRG 71_ CATQP 76_ CHHGA 81_ LCVPQ 86_ GPDPT 91_ GFRCY 96_ CVPGF 101_ QGPRC 106_ ELDID 111_ ECASR 116_ PCHHG 121_ ATCRN 126_ LADRY 131_ ECHCP 136_ LGYAG 141_ VTCEM 146_ EVDEC 151_ ASAPC 156_ LHGGS 161_ CLDGV 166_ GSFRC 171_ VCAPG 176_ YGGTR 181_ CQLDL 186_ DECQS 191_ QPCAH 196_ GGTCH 201_ DLVNG 206_ FRCDC 211_ AGTGY 216_ EGTHC 221_ EREVL 226_ ECASA 231_ PCEHN 236_ ASCLE 241_ GLGSF 246_ RCLCW 251_ PGYSG 256_ ELCEV 261_ DEDEC 266_ ASSPC 271_ QHGGR 276_ CLQRS 281_ DPALY 286_ GGVQA 291_ AFPGA 296_ FSFRH 301_ AAGFL 306_ CHCPP 311_ GFEGA 316_ DCGVE 321_ VDECA 326_ SRPCL 331_ NGGHC 336_ QDLPN 341_ GFQCH 346_ CPDGY 351_ AGPTC 356_ EEDVD 361_ ECLSD 366_ PCLHG 371_ GTCSD 376_ TVAGY 381_ ICRCP 386_ ETWGG 391_ RDCSV 396_ QLTGC 401_ QGHTC 406_ PLAAT 411_ CIPIF 416_ ESGVH 421_ SYVCH 426_ CPPGT 431_ HGPFC 436_ GQNTT 441_ FSVMA 446_ GSPIQ 451_ ASVPA 456_ GGPLG 461_ LALRF 466_ RTTLP 471_ AGTLA 476_ TRNDT 481_ KESLE 486_ LALVA 491_ ATLQA 496_ TLWSY 501_ STTVL 506_ VLRLP 511_ DLALN 516_ DGHWH 521_ QVEVV 526_ LHLAT 531_ LELRL 536_ WHEGC 541_ PARLC 546_ VASGP 551_ VALAS 556_ TASAT 561_ PLPAG 566_ ISSAQ 571_ LGDAT 576_ FAGCL 581_ QDVRV 586_ DGHLL 591_ LPEDL 596_ GENVL 601_ LGCER 606_ REQCR 611_ PLPCV 616_ HGGSC 621_ VDLWT 626_ HFRCD 631_ CARPH 636_ RGPTC 641_ ADEIP 646_ AATFG 651_ LGGAP 656_ SSASF 661_ LLQEL 666_ PGPNL 671_ TVSFL 676_ LRTRE 681_ SAGLL 686_ LQFAN 691_ DSAAG 696_ LTVFL 701_ SEGRI 706_ RAEVP 711_ GSPAV 716_ VLPGR 721_ WDDGL 726_ RHLVM 731_ LSFGP 736_ DQLQD 741_ LGQHV 746_ HVGGR 751_ LLAAD 756_ SQPWG 761_ GPFRG 766_ CLQDL 771_ RLDGC 776_ HLPFF 781_ PLPLD 786_ NSSQP 791_ SELGG 796_ RQSWN 801_ LTAGC 806_ VSEDM 811_ CSPDP 816_ CFNGG 821_ TCLVT 826_ WNDFH 831_ CTCPA 836_ NFTGP 841_ TCAQQ 846_ LWCPG 851_ QPCLP 856_ PATCE 861_ EVPDG 866_ FVCVA 871_ EATFR 876_ EGPPA 881_ AFSGH 886_ NASSG 891_ RLLGG 896_ LSLAF 901_ RTRDS 906_ EAWLL 911_ RAAAG 916_ ALEGV 921_ WLAVR 926_ NGSLA 931_ GGVRG 936_ GHGLP 941_ GAVLP 946_ IPGPR 951_ VADGA 956_ WHRVR 961_ LAMER 966_ PAATT 971_ SRWLL 976_ WLDGA 981_ ATPVA 986_ LRGLA 991_ SDLGF 996_ LQGPG 1001_ AVRIL 1006_ LAENF 1011_ TGCLG 1016_ RVALG 1021_ GLPLP 1026_ LARPR 1031_ PGAAP 1036_ GAREH 1041_ FASWP 1046_ GTPAP 1051_ ILGCR 1056_ GAPVC 1061_ APSPC 1066_ LHDGA 1071_ CRDLF 1076_ DAFAC 1081_ ACGPG 1086_ WEGPR 1091_ CEAHV 1096_ DPCHS 1101_ APCAR 1106_ GRCHT 1111_ HPDGR 1116_ FECRC 1121_ PPGFG 1126_ GPRCR 1131_ LPVPS 1136_ KECSL 1141_ NVTCL 1146_ DGSPC 1151_ EGGSP 1156_ AANCS 1161_ CLEGL 1166_ AGQRC 1171_ QVPTL 1176_ PCEAN 1181_ PCLNG 1186_ GTCRA 1191_ AGGVS 1196_ ECICN 1201_ ARFSG 1206_ QFCEV 1211_ AKGLP 1216_ LPLPF 1221_ PLLEV 1226_ AVPAA 1231_ CACLL 1236_ LLLLG 1241_ LLSGI 1246_ LAARK 1251_ RRQSE 1256_ GTYSP 1261_ SQQEV 1266_ AGARL 1271_ EMDSV 1276_LKVPP
1: Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (By similarity). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (By similarity). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (By similarity). Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness (By similarity). May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells (By similarity). Also required for maintenance of the apical polarity complex during development of the cortex (By similarity). Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription (PubMed:20299451)