ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85)
1_MTAQG 6_ GLVAN 11_ RGRRF 16_ KWAIE 21_ LSGPG 26_ GGSRG 31_ RSDRG 36_ SGQGD 41_ SLYPV 46_ GYLDK 51_ QVPDT 56_ SVQET 61_ DRILV 66_ EKRCW 71_ DIALG 76_ PLKQI 81_ PMNLF 86_ IMYMA 91_ GNTIS 96_ IFPTM 101_ MVCMM 106_ AWRPI 111_ QALMA 116_ ISATF 121_ KMLES 126_ SSQKF 131_ LQGLV 136_ YLIGN 141_ LMGLA 146_ LAVYK 151_ CQSMG 156_ LLPTH 161_ ASDWL 166_ AFIEP 171_ PERME 176_FSGGG
1: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)