Gene name: EARS2

Uniprot entry:

Q5JPH6

Protein names:

Probable glutamate--tRNA ligase, mitochondrial (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS)

Protein sequence:

1_MAALL 6_ RRLLQ 11_ RERPS 16_ AASGR 21_ PVGRR 26_ EANLG 31_ TDAGV 36_ AVRVR 41_ FAPSP 46_ TGFLH 51_ LGGLR 56_ TALYN 61_ YIFAK 66_ KYQGS 71_ FILRL 76_ EDTDQ 81_ TRVVP 86_ GAAEN 91_ IEDML 96_ EWAGI 101_ PPDES 106_ PRRGG 111_ PAGPY 116_ QQSQR 121_ LELYA 126_ QATEA 131_ LLKTG 136_ AAYPC 141_ FCSPQ 146_ RLELL 151_ KKEAL 156_ RNHQT 161_ PRYDN 166_ RCRNM 171_ SQEQV 176_ AQKLA 181_ KDPKP 186_ AIRFR 191_ LEQVV 196_ PAFQD 201_ LVYGW 206_ NRHEV 211_ ASVEG 216_ DPVIM 221_ KSDGF 226_ PTYHL 231_ ACVVD 236_ DHHMG 241_ ISHVL 246_ RGSEW 251_ LVSTA 256_ KHLLL 261_ YQALG 266_ WQPPH 271_ FAHLP 276_ LLLNR 281_ DGSKL 286_ SKRQG 291_ DVFLE 296_ HFAAD 301_ GFLPD 306_ SLLDI 311_ ITNCG 316_ SGFAE 321_ NQMGR 326_ TLPEL 331_ ITQFN 336_ LTQVT 341_ CHSAL 346_ LDLEK 351_ LPEFN 356_ RLHLQ 361_ RLVSN 366_ ESQRR 371_ QLVGK 376_ LQVLV 381_ EEAFG 386_ CQLQN 391_ RDVLN 396_ PVYVE 401_ RILLL 406_ RQGHI 411_ CRLQD 416_ LVSPV 421_ YSYLW 426_ TRPAV 431_ GRAQL 436_ DAISE 441_ KVDVI 446_ AKRVL 451_ GLLER 456_ SSMSL 461_ TQDML 466_ NGELK 471_ KLSEG 476_ LEGTK 481_ YSNVM 486_ KLLRM 491_ ALSGQ 496_ QQGPP 501_ VAEMM 506_ LALGP 511_ KEVRE 516_RIQKV

Protein annotations

Protein functions:

1: Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation (PubMed:19805282). Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln) (PubMed:19805282). In vitro, cytoplasmic tRNA(Gln) is slightly glutamylated, but with low activity (PubMed:19805282)