WD repeat-containing protein 44 (Rabphilin-11)
1_MASES 6_ DTEEF 11_ YDAPE 16_ DVHLG 21_ GGYPV 26_ GSPGK 31_ VGLST 36_ FKETE 41_ NTAYK 46_ VGNES 51_ PVQEL 56_ KQDVS 61_ KKIIE 66_ SIIEE 71_ SQKVL 76_ QLEDD 81_ SLDSK 86_ GKELS 91_ DQATA 96_ SPIVA 101_ RTDLS 106_ NIPGL 111_ LAIDQ 116_ VLPEE 121_ SQKAE 126_ SQNTF 131_ EETEL 136_ ELKKC 141_ FPSDE 146_ TCEKP 151_ VDETT 156_ KLTQT 161_ SSTEQ 166_ LNVLE 171_ TETEV 176_ LNKEA 181_ VEVKG 186_ GGDVL 191_ EPVSS 196_ DSLST 201_ KDFAA 206_ VEEVA 211_ PAKPP 216_ RHLTP 221_ EPDIV 226_ ASTKK 231_ PVPAR 236_ PPPPT 241_ NFPPP 246_ RPPPP 251_ SRPAP 256_ PPRKR 261_ KSELE 266_ FETLK 271_ TPDID 276_ VPKEN 281_ ITSDS 286_ LLTAS 291_ MASES 296_ TVKDS 301_ QPSLD 306_ LASAT 311_ SGDKI 316_ VTAQE 321_ NGKAP 326_ DGQTV 331_ AGEVM 336_ GPQRP 341_ RSNSG 346_ RELTD 351_ EEILA 356_ SVMIK 361_ NLDTG 366_ EEIPL 371_ SLAEE 376_ KLPTG 381_ INPLT 386_ LHIMR 391_ RTKEY 396_ VSNDA 401_ AQSDD 406_ EEKLQ 411_ SQPTD 416_ TDGGR 421_ LKQKT 426_ TQLKK 431_ FLGKS 436_ VKRAK 441_ HLAEE 446_ YGERA 451_ INKVK 456_ SVRDE 461_ VFHTD 466_ QDDPS 471_ SSDDE 476_ GMPYT 481_ RPVKF 486_ KAAHG 491_ FKGPY 496_ DFDQI 501_ KVVQD 506_ LSGEH 511_ MGAVW 516_ TMKFS 521_ HCGRL 526_ LASAG 531_ QDNVV 536_ RIWAL 541_ KNAFD 546_ YFNNM 551_ RMKYN 556_ TEGRV 561_ SPSPS 566_ QESLS 571_ SSKSD 576_ TDTGV 581_ CSGTD 586_ EDPDD 591_ KNAPF 596_ RQRPF 601_ CKYKG 606_ HTADL 611_ LDLSW 616_ SKNYF 621_ LLSSS 626_ MDKTV 631_ RLWHI 636_ SRREC 641_ LCCFQ 646_ HIDFV 651_ TAIAF 656_ HPRDD 661_ RYFLS 666_ GSLDG 671_ KLRLW 676_ NIPDK 681_ KVALW 686_ NEVDG 691_ QTKLI 696_ TAANF 701_ CQNGK 706_ YAVIG 711_ TYDGR 716_ CIFYD 721_ TEHLK 726_ YHTQI 731_ HVRST 736_ RGRNK 741_ VGRKI 746_ TGIEP 751_ LPGEN 756_ KILVT 761_ SNDSR 766_ IRLYD 771_ LRDLS 776_ LSMKY 781_ KGYVN 786_ SSSQI 791_ KASFS 796_ HDFTY 801_ LVSGS 806_ EDKYV 811_ YIWST 816_ YHDLS 821_ KFTSV 826_ RRDRN 831_ DFWEG 836_ IKAHN 841_ AVVTS 846_ AIFAP 851_ NPSLM 856_ LSLDV 861_ QSEKS 866_ EGNEK 871_ SEDAE 876_ VLDAT 881_ PSGIM 886_ KTDNT 891_ EVLLS 896_ ADFTG 901_ AIKVF 906_VNKRK
1: Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433)