Ras-related protein Rab-41
1_MSAFG 6_ HDEAW 11_ MEAGG 16_ FGLEA 21_ AERTE 26_ YQSLC 31_ KSKLL 36_ FLGEQ 41_ SVGKT 46_ SIISR 51_ FMYNS 56_ FGCAC 61_ QATVG 66_ IDFLS 71_ KTMYL 76_ EDQIV 81_ QLQLW 86_ DTAGQ 91_ ERFHS 96_ LIPSY 101_ IRDST 106_ IAVVV 111_ YDITN 116_ INSFK 121_ ETDKW 126_ VEHVR 131_ AERGD 136_ DVVIM 141_ LLGNK 146_ IDLDN 151_ KRQVT 156_ AEQGE 161_ EKSRN 166_ LNVMF 171_ IETSA 176_ KTGYN 181_ VKKLF 186_ RRVAS 191_ ALLST 196_ RTSPP 201_ PKEGT 206_ VEIEL 211_ ESFEE 216_SGNRS
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:23936529). RAB41 is required for normal Golgi ribbon organization and ER-to-Golgi trafficking (PubMed:23936529)