APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein)
1_METQK 6_ DEAAQ 11_ AKGAA 16_ ASGST 21_ REQTA 26_ EKGAK 31_ NKAAE 36_ ATEGP 41_ TSEPS 46_ SSGPG 51_ RLKKT 56_ AMKLF 61_ GGKKG 66_ ICTLP 71_ SFFGG 76_ GRSKG 81_ SGKGS 86_ SKKGL 91_ SKSKT 96_ HDGLS 101_ EAAHG 106_ PEDVV 111_ SEGTG 116_ FSLPL 121_ PELPC 126_ QFPSS 131_ QSAHG 136_ ALETG 141_ SRCKT 146_ SVAGA 151_ TEKAV 156_ AEKFP 161_ SMPKP 166_ KKGLK 171_ GFFSS 176_ IRRHR 181_ KSKVT 186_ GAEQS 191_ EPGAK 196_ GPERV 201_ RARPH 206_ EHVSS 211_ APQVP 216_ CFEET 221_ FQAPR 226_ KENAN 231_ PQDAP 236_ GPKVS 241_ PTPEP 246_ SPPAT 251_ EKMAC 256_ KDPEK 261_ PMEAC 266_ ASAHV 271_ QPKPA 276_ PEASS 281_ LEEPH 286_ SPETG 291_ EKVVA 296_ GEVNP 301_ PNGPV 306_ GDPLS 311_ LLFGD 316_ VTSLK 321_ SFDSL 326_ TGCGD 331_ IIAEQ 336_ DMDSM 341_ TDSMA 346_ SGGQR 351_ ANRDG 356_ TKRSS 361_ CLVTY 366_ QGGGE 371_ EMALP 376_ DDDDE 381_ EEEEE 386_ EEVEL 391_ EEEEE 396_ EVKEE 401_ EEDDD 406_ LEYLW 411_ ETAQM 416_ YPRPN 421_ MNLGY 426_ HPTTS 431_ PGHHG 436_ YMLLD 441_ PVRSY 446_ PGLAP 451_ GELLT 456_ PQSDQ 461_ QESAP 466_ NSDEG 471_ YYDST 476_ TPGFE 481_ DDSGE 486_ ALGLV 491_ RRDCL 496_ PRDSY 501_ SGDAL 506_ YEFYE 511_ PDDSL 516_ ENSPP 521_ GDDCL 526_ YDLHG 531_ RSSEM 536_ FDPFL 541_ NFEPF 546_ LSSRP 551_ PGAME 556_ TEEER 561_ LVTIQ 566_ KQLLY 571_ WELRR 576_ EQLEA 581_ QEARA 586_ REAHA 591_ REAHA 596_ REAYT 601_ REAYG 606_ REAYA 611_ REAHT 616_ WEAHG 621_ REART 626_ REAQA 631_ REVRC 636_ RETQV 641_ RETQA 646_ RQEKP 651_ VLEYQ 656_ MRPLG 661_ PSVMG 666_ LAAGV 671_ SGTSQ 676_ ISHRG 681_ ITSAF 686_ PTTAS 691_ SEPDW 696_ RDFRP 701_ LEKRY 706_ EGTCS 711_ KKDQS 716_ TCLMQ 721_ LFQSD 726_ AMFEP 731_ DMQEA 736_ NFGGS 741_ PRRAY 746_ PTYSP 751_ PEDPE 756_ EEEVE 761_ KEGNA 766_ TVSFS 771_ QALVE 776_ FTSNG 781_ NLFSS 786_ MSCSS 791_ DSDSS 796_ FTQNL 801_ PELPP 806_ MVTFD 811_ IADVE 816_ RDGEG 821_ KCEEN 826_ PEFHN 831_ DEDLA 836_ ASLEA 841_ FELGY 846_ YHKHA 851_ FNNYH 856_ SRFYQ 861_ GLPWG 866_ VSSLP 871_ RYLGL 876_ PGLHP 881_ RPPPA 886_ AMALN 891_ RRSRS 896_ LDTAE 901_ TLEME 906_ LSNSH 911_ LVQGY 916_ LESDE 921_ LQAQQ 926_ EDSDE 931_ EDEEE 936_ EEGEW 941_ SRDSP 946_ LSLYT 951_ EPPGA 956_ YDWPA 961_ WAPCP 966_ LPVGP 971_ GPAWI 976_ SPNQL 981_ DRPSS 986_ QSPYR 991_ QATCC 996_ IPPMT 1001_ MSISL 1006_ SVPES 1011_ RAPGE 1016_ SGPQL 1021_ ARPSH 1026_ LHLPM 1031_ GPCYN 1036_ LQPQA 1041_ SQSMR 1046_ ARPRD 1051_ VLLPV 1056_ DEPSC 1061_ SSSSG 1066_ GFSPS 1071_ PLPQA 1076_ KPVGI 1081_ THGIP 1086_ QLPRV 1091_ RPEHP 1096_ QPQPT 1101_ HYGPS 1106_ SLDLS 1111_ KERAE 1116_ QGASL 1121_ ATSYS 1126_STAMN
1: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development