Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)
1_MAASV 6_ AAAAR 11_ RLRRA 16_ IRRSP 21_ AWRGL 26_ SHRPL 31_ SSEPP 36_ AAKAS 41_ AVRAA 46_ FLNFF 51_ RDRHG 56_ HRLVP 61_ SASVR 66_ PRGDP 71_ SLLFV 76_ NAGMN 81_ QFKPI 86_ FLGTV 91_ DPRSE 96_ MAGFR 101_ RVANS 106_ QKCVR 111_ AGGHH 116_ NDLED 121_ VGRDL 126_ SHHTF 131_ FEMLG 136_ NWAFG 141_ GEYFK 146_ EEACN 151_ MAWEL 156_ LTQVY 161_ GIPEE 166_ RLWIS 171_ YFDGD 176_ PKAGL 181_ DPDLE 186_ TRDIW 191_ LSLGV 196_ PASRV 201_ LSFGP 206_ QENFW 211_ EMGDT 216_ GPCGP 221_ CTEIH 226_ YDLAG 231_ GVGAP 236_ QLVEL 241_ WNLVF 246_ MQHNR 251_ EADGS 256_ LQPLP 261_ QRHVD 266_ TGMGL 271_ ERLVA 276_ VLQGK 281_ HSTYD 286_ TDLFS 291_ PLLNA 296_ IQQGC 301_ RAPPY 306_ LGRVG 311_ VADEG 316_ RTDTA 321_ YRVVA 326_ DHIRT 331_ LSVCI 336_ SDGIF 341_ PGMSG 346_ PPLVL 351_ RRILR 356_ RAVRF 361_ SMEIL 366_ KAPPG 371_ FLGSL 376_ VPVVV 381_ ETLGD 386_ AYPEL 391_ QRNSA 396_ QIANL 401_ VSEDE 406_ AAFLA 411_ SLERG 416_ RRIID 421_ RTLRT 426_ LGPSD 431_ MFPAE 436_ VAWSL 441_ SLCGD 446_ LGLPL 451_ DMVEL 456_ MLEEK 461_ GVQLD 466_ SAGLE 471_ RLAQE 476_ EAQHR 481_ ARQAE 486_ PVQKQ 491_ GLWLD 496_ VHALG 501_ ELQRQ 506_ GVPPT 511_ DDSPK 516_ YNYSL 521_ RPSGS 526_ YEFGT 531_ CEAQV 536_ LQLYT 541_ EDGTA 546_ VASVG 551_ KGQRC 556_ GLLLD 561_ RTNFY 566_ AEQGG 571_ QASDR 576_ GYLVR 581_ AGQED 586_ VLFPV 591_ ARAQV 596_ CGGFI 601_ LHEAV 606_ APECL 611_ RLGDQ 616_ VQLHV 621_ DEAWR 626_ LGCMA 631_ KHTAT 636_ HLLNW 641_ ALRQT 646_ LGPGT 651_ EQQGS 656_ HLNPE 661_ QLRLD 666_ VTTQT 671_ PLTPE 676_ QLRAV 681_ ENTVQ 686_ EAVGQ 691_ DEAVY 696_ MEEVP 701_ LALTA 706_ QVPGL 711_ RSLDE 716_ VYPDP 721_ VRVVS 726_ VGVPV 731_ AHALD 736_ PASQA 741_ ALQTS 746_ VELCC 751_ GTHLL 756_ RTGAV 761_ GDLVI 766_ IGDRQ 771_ LSKGT 776_ TRLLA 781_ VTGEQ 786_ AQQAR 791_ ELGQS 796_ LAQEV 801_ KAATE 806_ RLSLG 811_ SRDVA 816_ EALRL 821_ SKDIG 826_ RLIEA 831_ VETAV 836_ MPQWQ 841_ RRELL 846_ ATVKM 851_ LQRRA 856_ NTAIR 861_ KLQMG 866_ QAAKK 871_ TQELL 876_ ERHSK 881_ GPLIV 886_ DTVSA 891_ ESLSV 896_ LVKVV 901_ RQLCE 906_ QAPST 911_ SVLLL 916_ SPQPM 921_ GKVLC 926_ ACQVA 931_ QGAMP 936_ TFTAE 941_ AWALA 946_ VCSHM 951_ GGKAW 956_ GSRVV 961_ AQGTG 966_ STTDL 971_ EAALS 976_IAQTY
1: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:21549344). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS (PubMed:39322678). Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:39322678)