PCI domain-containing protein 2 (CSN12-like protein)
1_MAHIT 6_ INQYL 11_ QQVYE 16_ AIDSR 21_ DGASC 26_ AELVS 31_ FKHPH 36_ VANPR 41_ LQMAS 46_ PEEKC 51_ QQVLE 56_ PPYDE 61_ MFAAH 66_ LRCTY 71_ AVGNH 76_ DFIEA 81_ YKCQT 86_ VIVQS 91_ FLRAF 96_ QAHKE 101_ ENWAL 106_ PVMYA 111_ VALDL 116_ RVFAN 121_ NADQQ 126_ LVKKG 131_ KSKVG 136_ DMLEK 141_ AAELL 146_ MSCFR 151_ VCASD 156_ TRAGI 161_ EDSKK 166_ WGMLF 171_ LVNQL 176_ FKIYF 181_ KINKL 186_ HLCKP 191_ LIRAI 196_ DSSNL 201_ KDDYS 206_ TAQRV 211_ TYKYY 216_ VGRKA 221_ MFDSD 226_ FKQAE 231_ EYLSF 236_ AFEHC 241_ HRSSQ 246_ KNKRM 251_ ILIYL 256_ LPVKM 261_ LLGHM 266_ PTVEL 271_ LKKYH 276_ LMQFA 281_ EVTRA 286_ VSEGN 291_ LLLLH 296_ EALAK 301_ HEAFF 306_ IRCGI 311_ FLILE 316_ KLKII 321_ TYRNL 326_ FKKVY 331_ LLLKT 336_ HQLSL 341_ DAFLV 346_ ALKFM 351_ QVEDV 356_ DIDEV 361_ QCILA 366_ NLIYM 371_ GHVKG 376_ YISHQ 381_ HQKLV 386_ VSKQN 391_PFPPL
1: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity)