Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen)
1_MKGAL 6_ GSPVA 11_ AAGAA 16_ MQESF 21_ GCVVA 26_ NRFHQ 31_ LLDDE 36_ SDPFD 41_ ILREA 46_ ERRRQ 51_ QQLQR 56_ KRRDE 61_ AAAAA 66_ GAGPR 71_ GGRSP 76_ AGASG 81_ HRAGA 86_ GGRRE 91_ SQKER 96_ KSLPA 101_ PVAQR 106_ PDSPG 111_ GGLQA 116_ PGQKR 121_ TPRRG 126_ EQQGW 131_ NDSRG 136_ PEGML 141_ ERAER 146_ RSYRE 151_ YRPYE 156_ TERQA 161_ DFTAE 166_ KFPDE 171_ KPGDR 176_ FDRDR 181_ PLRGR 186_ GGPRG 191_ GMRGR 196_ GRGGP 201_ GNRVF 206_ DAFDQ 211_ RGKRE 216_ FERYG 221_ GNDKI 226_ AVRTE 231_ DNMGG 236_ CGVRT 241_ WGSGK 246_ DTSDV 251_ EPTAP 256_ MEEPT 261_ VVEES 266_ QGTPE 271_ EESPA 276_ KVPEL 281_ EVEEE 286_ TQVQE 291_ MTLDE 296_ WKNLQ 301_ EQTRP 306_ KPEFN 311_ IRKPE 316_ STVPS 321_ KAVVI 326_ HKSKY 331_ RDDMV 336_ KDDYE 341_ DDSHV 346_ FRKPA 351_ NDITS 356_ QLEIN 361_ FGNLP 366_ RPGRG 371_ ARGGT 376_ RGGRG 381_ RIRRA 386_ ENYGP 391_ RAEVV 396_ MQDVA 401_ PNPDD 406_PEDFP
1: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity)