Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas)
1_MGVRN 6_ CLYGN 11_ NMSGQ 16_ RDIPP 21_ EIGEQ 26_ PEQPP 31_ LEAPG 36_ AAAPG 41_ AGPSP 46_ AEEME 51_ TEPPH 56_ NEPIP 61_ VENDG 66_ EACGP 71_ PEVSR 76_ PNFQV 81_ LNPAF 86_ REAGA 91_ HGSYS 96_ PPPEE 101_ AMPFE 106_ AEQPS 111_ LGGFW 116_ PTLEQ 121_ PGFPS 126_ GVHAG 131_ LEAFG 136_ PALME 141_ PGAFS 146_ GARPG 151_ LGGYS 156_ PPPEE 161_ AMPFE 166_ FDQPA 171_ QRGCS 176_ QLLLQ 181_ VPDLA 186_ PGGPG 191_ AAGVP 196_ GAPPE 201_ EPQAL 206_ RPAKA 211_ GSRGG 216_ YSPPP 221_ EETMP 226_ FELDG 231_ EGFGD 236_ DSPPP 241_ GLSRV 246_ IAQVD 251_ GSSQF 256_ AAVAA 261_ SSAVR 266_ LTPAA 271_ NAPPL 276_ WVPGA 281_ IGSPS 286_ QEAVR 291_ PPSNF 296_ TGSSP 301_ WMEIS 306_ GPPFE 311_ IGSAP 316_ AGVDD 321_ TPVNM 326_ DSPPI 331_ ALDGP 336_ PIKVS 341_ GAPDK 346_ RERAE 351_ RPPVE 356_ EEAAE 361_ MEGAA 366_ DAAEG 371_ GKVPS 376_ PGYGS 381_ PAAGA 386_ ASADT 391_ AARAA 396_ PAAPA 401_ DPDSG 406_ ATPED 411_ PDSGT 416_ APADP 421_ DSGAF 426_ AADPD 431_ SGAAP 436_ AAPAD 441_ PDSGA 446_ APDAP 451_ ADPDS 456_ GAAPD 461_ APADP 466_ DAGAA 471_ PEAPA 476_ APAAA 481_ ETRAA 486_ HVAPA 491_ APDAG 496_ APTAP 501_ AASAT 506_ RAAQV 511_ RRAAS 516_ AAPAS 521_ GARRK 526_ IHLRP 531_ PSPEI 536_ QAADP 541_ PTPRP 546_ TRASA 551_ WRGKS 556_ ESSRG 561_ RRVYY 566_ DEGVA 571_ SSDDD 576_ SSGDE 581_ SDDGT 586_ SGCLR 591_ WFQHR 596_ RNRRR 601_ RKPQR 606_ NLLRN 611_ FLVQA 616_ FGGCF 621_ GRSES 626_ PQPKA 631_ SRSLK 636_ VKKVP 641_ LAEKR 646_ RQMRK 651_ EALEK 656_ RAQKR 661_ AEKKR 666_ SKLID 671_ KQLQD 676_ EKMGY 681_ MCTHR 686_ LLLLG 691_ AGESG 696_ KSTIV 701_ KQMRI 706_ LHVNG 711_ FNGEG 716_ GEEDP 721_ QAARS 726_ NSDGE 731_ KATKV 736_ QDIKN 741_ NLKEA 746_ IETIV 751_ AAMSN 756_ LVPPV 761_ ELANP 766_ ENQFR 771_ VDYIL 776_ SVMNV 781_ PDFDF 786_ PPEFY 791_ EHAKA 796_ LWEDE 801_ GVRAC 806_ YERSN 811_ EYQLI 816_ DCAQY 821_ FLDKI 826_ DVIKQ 831_ ADYVP 836_ SDQDL 841_ LRCRV 846_ LTSGI 851_ FETKF 856_ QVDKV 861_ NFHMF 866_ DVGGQ 871_ RDERR 876_ KWIQC 881_ FNDVT 886_ AIIFV 891_ VASSS 896_ YNMVI 901_ REDNQ 906_ TNRLQ 911_ EALNL 916_ FKSIW 921_ NNRWL 926_ RTISV 931_ ILFLN 936_ KQDLL 941_ AEKVL 946_ AGKSK 951_ IEDYF 956_ PEFAR 961_ YTTPE 966_ DATPE 971_ PGEDP 976_ RVTRA 981_ KYFIR 986_ DEFLR 991_ ISTAS 996_ GDGRH 1001_ YCYPH 1006_ FTCAV 1011_ DTENI 1016_ RRVFN 1021_ DCRDI 1026_ IQRMH 1031_LRQYE
1: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms