Gene name: RNFT1

Uniprot entry:

Q5M7Z0

Protein names:

E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1)

Protein sequence:

1_MPLFL 6_ LSLPT 11_ PPSAS 16_ GHERR 21_ QRPEA 26_ KTSGS 31_ EKKYL 36_ RAMQA 41_ NRSQL 46_ HSPPG 51_ TGSSE 56_ DASTP 61_ QCVHT 66_ RLTGE 71_ GSCPH 76_ SGDVH 81_ IQINS 86_ IPKEC 91_ AENAS 96_ SRNIR 101_ SGVHS 106_ CAHGC 111_ VHSRL 116_ RGHSH 121_ SEARL 126_ TDDTA 131_ AESGD 136_ HGSSS 141_ FSEFR 146_ YLFKW 151_ LQKSL 156_ PYILI 161_ LSVKL 166_ VMQHI 171_ TGISL 176_ GIGLL 181_ TTFMY 186_ ANKSI 191_ VNQVF 196_ LRERS 201_ SKIQC 206_ AWLLV 211_ FLAGS 216_ SVLLY 221_ YTFHS 226_ QSLYY 231_ SLIFL 236_ NPTLD 241_ HLSFW 246_ EVFWI 251_ VGITD 256_ FILKF 261_ FFMGL 266_ KCLIL 271_ LVPSF 276_ IMPFK 281_ SKGYW 286_ YMLLE 291_ ELCQY 296_ YRTFV 301_ PIPVW 306_ FRYLI 311_ SYGEF 316_ GNVTR 321_ WSLGI 326_ LLALL 331_ YLILK 336_ LLEFF 341_ GHLRT 346_ FRQVL 351_ RIFFT 356_ QPSYG 361_ VAASK 366_ RQCSD 371_ VDDIC 376_ SICQA 381_ EFQKP 386_ ILLIC 391_ QHIFC 396_ EECMT 401_ LWFNR 406_ EKTCP 411_ LCRTV 416_ ISDHI 421_ NKWKD 426_GATSS

Protein annotations

Protein functions:

1: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis