Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1)
1_MRHNQ 6_ MCCET 11_ PPTVT 16_ VYVKS 21_ GSNRS 26_ HQPKK 31_ PITLK 36_ RPICK 41_ DNWQA 46_ FEKNT 51_ HNNNK 56_ SKRPK 61_ GPCLV 66_ IQRQD 71_ MTAFF 76_ KLFDD 81_ DLIQD 86_ FLWMD 91_ CCCKI 96_ ADKYL 101_ LAMTF 106_ VYFKR 111_ AKFTI 116_ SEHTR 121_ INFFI 126_ ALYLA 131_ NTVEE 136_ DEEET 141_ KYEIF 146_ PWALG 151_ KNWRK 156_ LFPNF 161_ LKLRD 166_ QLWDR 171_ IDYRA 176_ IVSRR 181_ CCEEV 186_ MAIAP 191_ THYIW 196_ QRERS 201_ VHHSG 206_ AVRNY 211_ NRDEV 216_ QLPRG 221_ PSATP 226_ VDCSL 231_ CGKKR 236_ RYVRL 241_ GLSSS 246_ SSLSS 251_ HTAGV 256_ TEKHS 261_ QDSYN 266_ SLSMD 271_ IIGDP 276_ SQAYT 281_ GSEVV 286_ NDHQS 291_ NKGKK 296_ TNFLK 301_ KDKSM 306_EWFTG
1: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962)