WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein)
1_MNLLP 6_ CNPHG 11_ NGLLY 16_ AGFNQ 21_ DHGCF 26_ ACGME 31_ NGFRV 36_ YNTDP 41_ LKEKE 46_ KQEFL 51_ EGGVG 56_ HVEML 61_ FRCNY 66_ LALVG 71_ GGKKP 76_ KYPPN 81_ KVMIW 86_ DDLKK 91_ KTVIE 96_ IEFST 101_ EVKAV 106_ KLRRD 111_ RIVVV 116_ LDSMI 121_ KVFTF 126_ THNPH 131_ QLHVF 136_ ETCYN 141_ PKGLC 146_ VLCPN 151_ SNNSL 156_ LAFPG 161_ THTGH 166_ VQLVD 171_ LASTE 176_ KPPVD 181_ IPAHE 186_ GVLSC 191_ IALNL 196_ QGTRI 201_ ATASE 206_ KGTLI 211_ RIFDT 216_ SSGHL 221_ IQELR 226_ RGSQA 231_ ANIYC 236_ INFNQ 241_ DASLI 246_ CVSSD 251_ HGTVH 256_ IFAAE 261_ DPKRN 266_ KQSSL 271_ ASASF 276_ LPKYF 281_ SSKWS 286_ FSKFQ 291_ VPSGS 296_ PCICA 301_ FGTEP 306_ NAVIA 311_ ICADG 316_ SYYKF 321_ LFNPK 326_ GECIR 331_ DVYAQ 336_FLEMT
1: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066, PubMed:30797857). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735)