WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa)
1_MEAEA 6_ ADAPP 11_ GGVES 16_ ALSCF 21_ SFNQD 26_ CTSLA 31_ TGTKA 36_ GYKLF 41_ SLSSV 46_ EQLDQ 51_ VHGSN 56_ EIPDV 61_ YIVER 66_ LFSSS 71_ LVVVV 76_ SHTKP 81_ RQMNV 86_ YHFKK 91_ GTEIC 96_ NYSYS 101_ SNILS 106_ IRLNR 111_ QRLLV 116_ CLEES 121_ IYIHN 126_ IKDMK 131_ LLKTL 136_ LDIPA 141_ NPTGL 146_ CALSI 151_ NHSNS 156_ YLAYP 161_ GSLTS 166_ GEIVL 171_ YDGNS 176_ LKTVC 181_ TIAAH 186_ EGTLA 191_ AITFN 196_ ASGSK 201_ LASAS 206_ EKGTV 211_ IRVFS 216_ VPDGQ 221_ KLYEF 226_ RRGMK 231_ RYVTI 236_ SSLVF 241_ SMDSQ 246_ FLCAS 251_ SNTET 256_ VHIFK 261_ LEQVT 266_ NSRPE 271_ EPSTW 276_ SGYMG 281_ KMFMA 286_ ATNYL 291_ PTQVS 296_ DMMHQ 301_ DRAFA 306_ TARLN 311_ FSGQR 316_ NICTL 321_ STIQK 326_ LPRLL 331_ VASSS 336_ GHLYM 341_ YNLDP 346_ QDGGE 351_ CVLIK 356_ THSLL 361_ GSGTT 366_ EENKE 371_ NDLRP 376_ SLPQS 381_ YAATV 386_ ARPSA 391_ SSAST 396_ VPGYS 401_ EDGGA 406_ LRGEV 411_ IPEHE 416_ FATGP 421_ VCLDD 426_ ENEFP 431_ PIILC 436_ RGNQK 441_GKTKQ
1: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:15602573, PubMed:20114074, PubMed:20484055, PubMed:20639694, PubMed:23088497, PubMed:28561066, PubMed:31271352). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066, PubMed:31271352, PubMed:33499712). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Together with WDR45/WIPI4, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Involved in xenophagy of Staphylococcus aureus (PubMed:22829830). Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation (PubMed:22829830). Also plays a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy (PubMed:21317285). May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway (PubMed:15020712)