Rab GTPase-activating protein 1-like
1_MEVRA 6_ SLQKV 11_ SGSSD 16_ SVATM 21_ NSEEF 26_ VLVPQ 31_ YADDN 36_ STKHE 41_ EKPQL 46_ KIVSN 51_ GDEQL 56_ EKAME 61_ EILRD 66_ SEKRP 71_ SSLLV 76_ DCQSS 81_ SEISD 86_ HSFGD 91_ IPASQ 96_ TNKPS 101_ LQLIL 106_ DPSNT 111_ EISTP 116_ RPSSP 121_ GGLPE 126_ EDSVL 131_ FNKLT 136_ YLGCM 141_ KVSSP 146_ RNEVE 151_ ALRAM 156_ ATMKS 161_ SSQYP 166_ FPVTL 171_ YVPNV 176_ PEGSV 181_ RIIDQ 186_ SSNVE 191_ IASFP 196_ IYKVL 201_ FCARG 206_ HDGTT 211_ ESNCF 216_ AFTES 221_ SHGSE 226_ EFQIH 231_ VFSCE 236_ IKEAV 241_ SRILY 246_ SFCTA 251_ FKRSS 256_ RQVSD 261_ VKDSV 266_ IPTPD 271_ SDVFT 276_ FSVSL 281_ EVKED 286_ DGKGN 291_ FSPVP 296_ KDRDK 301_ FYFKL 306_ KQGIE 311_ KKVVI 316_ TVQQL 321_ SNKEL 326_ AIERC 331_ FGMLL 336_ SPGRN 341_ VKNSD 346_ MHLLD 351_ MESMG 356_ KSYDG 361_ RAYVI 366_ TGMWN 371_ PNAPV 376_ FLALN 381_ EETPK 386_ DKQVY 391_ MTVAV 396_ DMVVT 401_ EVVEP 406_ VRFLL 411_ ETVVR 416_ VYPAN 421_ ERFWY 426_ FSRKT 431_ FTETF 436_ FMRLK 441_ QSEGK 446_ GHTNA 451_ GDAIY 456_ EVVSL 461_ QRESD 466_ KEEPV 471_ TPTSG 476_ GGPMS 481_ PQDDE 486_ AEEES 491_ DNELS 496_ SGTGD 501_ VSKDC 506_ PEKIL 511_ YSWGE 516_ LLGKW 521_ HSNLG 526_ ARPKG 531_ LSTLV 536_ KSGVP 541_ EALRA 546_ EVWQL 551_ LAGCH 556_ DNQAM 561_ LDRYR 566_ ILITK 571_ DSAQE 576_ SVITR 581_ DIHRT 586_ FPAHD 591_ YFKDT 596_ GGDGQ 601_ ESLYK 606_ ICKAY 611_ SVYDE 616_ DIGYC 621_ QGQSF 626_ LAAVL 631_ LLHMP 636_ EEQAF 641_ CVLVK 646_ IMYDY 651_ GLRDL 656_ YRNNF 661_ EDLHC 666_ KFYQL 671_ ERLMQ 676_ EQLPD 681_ LHSHF 686_ SDLNL 691_ EAHMY 696_ ASQWF 701_ LTLFT 706_ AKFPL 711_ CMVFH 716_ IIDLL 721_ LCEGL 726_ NIIFH 731_ VALAL 736_ LKTSK 741_ EDLLQ 746_ ADFEG 751_ ALKFF 756_ RVQLP 761_ KRYRA 766_ EENAR 771_ RLMEQ 776_ ACNIK 781_ VPTKK 786_ LKKYE 791_ KEYQT 796_ MRESQ 801_ LQQED 806_PMDRY
1: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity)