COBW domain-containing protein 5 (Cobalamin synthase W domain-containing protein 5)
1_MLPAV 6_ GSVDE 11_ EEDPA 16_ EEDCP 21_ ELVPI 26_ ETTQS 31_ EEEEK 36_ SGLGA 41_ KIPVT 46_ IITGY 51_ LGAGK 56_ TTLLN 61_ YILTE 66_ QHSKR 71_ VAVIL 76_ NESGE 81_ GSALE 86_ KSLAV 91_ SQGGE 96_ LYEEW 101_ LELRN 106_ GCLCC 111_ SVKDN 116_ GLRAI 121_ ENLMQ 126_ KKGKF 131_ DDILL 136_ ETTGL 141_ ADPGA 146_ VTSMF 151_ WVDAE 156_ LGSDI 161_ YLDGI 166_ ITIVD 171_ SKYGL 176_ KHLTE 181_ EKPDG 186_ LINEA 191_ TRQVA 196_ LADII 201_ LINKT 206_ DLVPE 211_ EDVKK 216_ LRTTI 221_ RSING 226_ LGQIL 231_ ETQRS 236_ RVDLS 241_ NVLDL 246_ HAFDS 251_ LSGIS 256_ LQKKL 261_ QHVPG 266_ TQPHL 271_ DQSIV 276_ TITFE 281_ VPGNA 286_ KEEHL 291_ NMFIQ 296_ NLLWE 301_ KNVRN 306_ KDNHC 311_ MEVIR 316_ LKGLV 321_ SIKDK 326_ SQQVI 331_ VQGVH 336_ ELYDL 341_ EETPV 346_ SWKDD 351_ TERTN 356_ RLVLI 361_ GRNLD 366_ KDILK 371_ QLFIA 376_ TVTET 381_ EKQWT 386_THFKE
1: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1