Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
1_MASGS 6_ CQGCE 11_ EDEET 16_ LKKLI 21_ VRLNN 26_ VQEGK 31_ QIETL 36_ VQILE 41_ DLLVF 46_ TYSER 51_ ASKLF 56_ QGKNI 61_ HVPLL 66_ IVLDS 71_ YMRVA 76_ SVQQV 81_ GWSLL 86_ CKLIE 91_ VCPGT 96_ MQSLM 101_ GPQDV 106_ GNDWE 111_ VLGVH 116_ QLILK 121_ MLTVH 126_ NASVN 131_ LSVIG 136_ LKTLD 141_ LLLTS 146_ GKITL 151_ LILDE 156_ ESDIF 161_ MLIFD 166_ AMHSF 171_ PANDE 176_ VQKLG 181_ CKALH 186_ VLFER 191_ VSEEQ 196_ LTEFV 201_ ENKDY 206_ MILLS 211_ ALTNF 216_ KDEEE 221_ IVLHV 226_ LHCLH 231_ SLAIP 236_ CNNVE 241_ VLMSG 246_ NVRCY 251_ NIVVE 256_ AMKAF 261_ PMSER 266_ IQEVS 271_ CCLLH 276_ RLTLG 281_ NFFNI 286_ LVLNE 291_ VHEFV 296_ VKAVQ 301_ QYPEN 306_ AALQI 311_ SALSC 316_ LALLT 321_ ETIFL 326_ NQDLE 331_ EKNEN 336_ QENDD 341_ EGEED 346_ KLFWL 351_ EACYK 356_ ALTWH 361_ RKNKH 366_ VQEAA 371_ CWALN 376_ NLLMY 381_ QNSLH 386_ EKIGD 391_ EDGHF 396_ PAHRE 401_ VMLSM 406_ LMHSS 411_ SKEVF 416_ QASAN 421_ ALSTL 426_ LEQNV 431_ NFRKI 436_ LLSKG 441_ IHLNV 446_ LELMQ 451_ KHIHS 456_ PEVAE 461_ SGCKM 466_ LNHLF 471_ EGSNT 476_ SLDIM 481_ AAVVP 486_ KILTV 491_ MKRHE 496_ TSLPV 501_ QLEAL 506_ RAILH 511_ FIVPG 516_ MPEES 521_ REDTE 526_ FHHKL 531_ NMVKK 536_ QCFKN 541_ DIHKL 546_ VLAAL 551_ NRFIG 556_ NPGIQ 561_ KCGLK 566_ VISSI 571_ VHFPD 576_ ALEML 581_ SLEGA 586_ MDSVL 591_ HTLQM 596_ YPDDQ 601_ EIQCL 606_ GLSLI 611_ GYLIT 616_ KKNVF 621_ IGTGH 626_ LLAKI 631_ LVSSL 636_ YRFKD 641_ VAEIQ 646_ TKGFQ 651_ TILAI 656_ LKLSA 661_ SFSKL 666_ LVHHS 671_ FDLVI 676_ FHQMS 681_ SNIME 686_ QKDQQ 691_ FLNLC 696_ CKCFA 701_ KVAMD 706_ DYLKN 711_ VMLER 716_ ACDQN 721_ NSIMV 726_ ECLLL 731_ LGADA 736_ NQAKE 741_ GSSLI 746_ CQVCE 751_ KESSP 756_ KLVEL 761_ LLNSG 766_ SREQD 771_ VRKAL 776_ TISIG 781_ KGDSQ 786_ IISLL 791_ LRRLA 796_ LDVAN 801_ NSICL 806_ GGFCI 811_ GKVEP 816_ SWLGP 821_ LFPDK 826_ TSNLR 831_ KQTNI 836_ ASTLA 841_ RMVIR 846_ YQMKS 851_ AVEEG 856_ TASGS 861_ DGNFS 866_ EDVLS 871_ KFDEW 876_ TFIPD 881_ SSMDS 886_ VFAQS 891_ DDLDS 896_ EGSEG 901_ SFLVK 906_ KKSNS 911_ ISVGE 916_ FYRDA 921_ VLQRC 926_ SPNLQ 931_ RHSNS 936_ LGPIF 941_ DHEDL 946_ LKRKR 951_ KILSS 956_ DDSLR 961_ SSKLQ 966_ SHMRH 971_ SDSIS 976_ SLASE 981_ REYIT 986_ SLDLS 991_ ANELR 996_ DIDAL 1001_ SQKCC 1006_ ISVHL 1011_ EHLEK 1016_ LELHQ 1021_ NALTS 1026_ FPQQL 1031_ CETLK 1036_ SLTHL 1041_ DLHSN 1046_ KFTSF 1051_ PSYLL 1056_ KMSCI 1061_ ANLDV 1066_ SRNDI 1071_ GPSVV 1076_ LDPTV 1081_ KCPTL 1086_ KQFNL 1091_ SYNQL 1096_ SFVPE 1101_ NLTDV 1106_ VEKLE 1111_ QLILE 1116_ GNKIS 1121_ GICSP 1126_ LRLKE 1131_ LKILN 1136_ LSKNH 1141_ ISSLS 1146_ ENFLE 1151_ ACPKV 1156_ ESFSA 1161_ RMNFL 1166_ AAMPF 1171_ LPPSM 1176_ TILKL 1181_ SQNKF 1186_ SCIPE 1191_ AILNL 1196_ PHLRS 1201_ LDMSS 1206_ NDIQY 1211_ LPGPA 1216_ HWKSL 1221_ NLREL 1226_ LFSHN 1231_ QISIL 1236_ DLSEK 1241_ AYLWS 1246_ RVEKL 1251_ HLSHN 1256_ KLKEI 1261_ PPEIG 1266_ CLENL 1271_ TSLDV 1276_ SYNLE 1281_ LRSFP 1286_ NEMGK 1291_ LSKIW 1296_ DLPLD 1301_ ELHLN 1306_ FDFKH 1311_ IGCKA 1316_ KDIIR 1321_ FLQQR 1326_ LKKAV 1331_ PYNRM 1336_ KLMIV 1341_ GNTGS 1346_ GKTTL 1351_ LQQLM 1356_ KTKKS 1361_ DLGMQ 1366_ SATVG 1371_ IDVKD 1376_ WPIQI 1381_ RDKRK 1386_ RDLVL 1391_ NVWDF 1396_ AGREE 1401_ FYSTH 1406_ PHFMT 1411_ QRALY 1416_ LAVYD 1421_ LSKGQ 1426_ AEVDA 1431_ MKPWL 1436_ FNIKA 1441_ RASSS 1446_ PVILV 1451_ GTHLD 1456_ VSDEK 1461_ QRKAC 1466_ MSKIT 1471_ KELLN 1476_ KRGFP 1481_ AIRDY 1486_ HFVNA 1491_ TEESD 1496_ ALAKL 1501_ RKTII 1506_ NESLN 1511_ FKIRD 1516_ QLVVG 1521_ QLIPD 1526_ CYVEL 1531_ EKIIL 1536_ SERKN 1541_ VPIEF 1546_ PVIDR 1551_ KRLLQ 1556_ LVREN 1561_ QLQLD 1566_ ENELP 1571_ HAVHF 1576_ LNESG 1581_ VLLHF 1586_ QDPAL 1591_ QLSDL 1596_ YFVEP 1601_ KWLCK 1606_ IMAQI 1611_ LTVKV 1616_ EGCPK 1621_ HPKGI 1626_ ISRRD 1631_ VEKFL 1636_ SKKRK 1641_ FPKNY 1646_ MSQYF 1651_ KLLEK 1656_ FQIAL 1661_ PIGEE 1666_ YLLVP 1671_ SSLSD 1676_ HRPVI 1681_ ELPHC 1686_ ENSEI 1691_ IIRLY 1696_ EMPYF 1701_ PMGFW 1706_ SRLIN 1711_ RLLEI 1716_ SPYML 1721_ SGRER 1726_ ALRPN 1731_ RMYWR 1736_ QGIYL 1741_ NWSPE 1746_ AYCLV 1751_ GSEVL 1756_ DNHPE 1761_ SFLKI 1766_ TVPSC 1771_ RKGCI 1776_ LLGQV 1781_ VDHID 1786_ SLMEE 1791_ WFPGL 1796_ LEIDI 1801_ CGEGE 1806_ TLLKK 1811_ WALYS 1816_ FNDGE 1821_ EHQKI 1826_ LLDDL 1831_ MKKAE 1836_ EGDLL 1841_ VNPDQ 1846_ PRLTI 1851_ PISQI 1856_ APDLI 1861_ LADLP 1866_ RNIML 1871_ NNDEL 1876_ EFEQA 1881_ PEFLL 1886_ GDGSF 1891_ GSVYR 1896_ AAYEG 1901_ EEVAV 1906_ KIFNK 1911_ HTSLR 1916_ LLRQE 1921_ LVVLC 1926_ HLHHP 1931_ SLISL 1936_ LAAGI 1941_ RPRML 1946_ VMELA 1951_ SKGSL 1956_ DRLLQ 1961_ QDKAS 1966_ LTRTL 1971_ QHRIA 1976_ LHVAD 1981_ GLRYL 1986_ HSAMI 1991_ IYRDL 1996_ KPHNV 2001_ LLFTL 2006_ YPNAA 2011_ IIAKI 2016_ ADYGI 2021_ AQYCC 2026_ RMGIK 2031_ TSEGT 2036_ PGFRA 2041_ PEVAR 2046_ GNVIY 2051_ NQQAD 2056_ VYSFG 2061_ LLLYD 2066_ ILTTG 2071_ GRIVE 2076_ GLKFP 2081_ NEFDE 2086_ LEIQG 2091_ KLPDP 2096_ VKEYG 2101_ CAPWP 2106_ MVEKL 2111_ IKQCL 2116_ KENPQ 2121_ ERPTS 2126_ AQVFD 2131_ ILNSA 2136_ ELVCL 2141_ TRRIL 2146_ LPKNV 2151_ IVECM 2156_ VATHH 2161_ NSRNA 2166_ SIWLG 2171_ CGHTD 2176_ RGQLS 2181_ FLDLN 2186_ TEGYT 2191_ SEEVA 2196_ DSRIL 2201_ CLALV 2206_ HLPVE 2211_ KESWI 2216_ VSGTQ 2221_ SGTLL 2226_ VINTE 2231_ DGKKR 2236_ HTLEK 2241_ MTDSV 2246_ TCLYC 2251_ NSFSK 2256_ QSKQK 2261_ NFLLV 2266_ GTADG 2271_ KLAIF 2276_ EDKTV 2281_ KLKGA 2286_ APLKI 2291_ LNIGN 2296_ VSTPL 2301_ MCLSE 2306_ STNST 2311_ ERNVM 2316_ WGGCG 2321_ TKIFS 2326_ FSNDF 2331_ TIQKL 2336_ IETRT 2341_ SQLFS 2346_ YAAFS 2351_ DSNII 2356_ TVVVD 2361_ TALYI 2366_ AKQNS 2371_ PVVEV 2376_ WDKKT 2381_ EKLCG 2386_ LIDCV 2391_ HFLRE 2396_ VMVKE 2401_ NKESK 2406_ HKMSY 2411_ SGRVK 2416_ TLCLQ 2421_ KNTAL 2426_ WIGTG 2431_ GGHIL 2436_ LLDLS 2441_ TRRLI 2446_ RVIYN 2451_ FCNSV 2456_ RVMMT 2461_ AQLGS 2466_ LKNVM 2471_ LVLGY 2476_ NRKNT 2481_ EGTQK 2486_ QKEIQ 2491_ SCLTV 2496_ WDINL 2501_ PHEVQ 2506_ NLEKH 2511_ IEVRK 2516_ ELAEK 2521_MRRTS
1: Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290)