Phytanoyl-CoA dioxygenase domain-containing protein 1 (Protein PHYHD1) (EC 1.14.11.-)
1_MACLS 6_ PSQLQ 11_ KFQQD 16_ GFLVL 21_ EGFLS 26_ AEECV 31_ AMQQR 36_ IGEIV 41_ AEMDV 46_ PLHCR 51_ TEFST 56_ QEEEQ 61_ LRAQG 66_ STDYF 71_ LSSGD 76_ KIRFF 81_ FEKGV 86_ FDEKG 91_ NFLVP 96_ PEKSI 101_ NKIGH 106_ ALHAH 111_ DPVFK 116_ SITHS 121_ FKVQT 126_ LARSL 131_ GLQMP 136_ VVVQS 141_ MYIFK 146_ QPHFG 151_ GEVSP 156_ HQDAS 161_ FLYTE 166_ PLGRV 171_ LGVWI 176_ AVEDA 181_ TLENG 186_ CLWFI 191_ PGSHT 196_ SGVSR 201_ RMVRA 206_ PVGSA 211_ PGTSF 216_ LGSEP 221_ ARDNS 226_ LFVPT 231_ PVQRG 236_ ALVLI 241_ HGEVV 246_ HKSKQ 251_ NLSDR 256_ SRQAY 261_ TFHLM 266_ EASGT 271_ TWSPE 276_ NWLQP 281_ TAELP 286_FPQLY
1: 2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner (PubMed:21530488). However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism (PubMed:21530488). Does not show detectable activity towards fatty acid CoA thioesters (PubMed:21530488)
2: Isoform 2 probably lacks enzyme activity
3: Isoform 3 probably lacks enzyme activity