PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1)
1_MENFQ 6_ YSVQL 11_ SDQDW 16_ AEFSA 21_ TADEC 26_ GLLQA 31_ GLASG 36_ DELLS 41_ SDIDQ 46_ GDSSG 51_ SSPPR 56_ APPLP 61_ TGQLA 66_ AGGRS 71_ RRGCE 76_ EEDVA 81_ TQQPV 86_ SRSQG 91_ EPVLA 96_ LGTGQ 101_ QTPST 106_ SARAE 111_ APPSL 116_ GPGAS 121_ PPSQF 126_ SSCPG 131_ PASSG 136_ DQMQR 141_ LLQGP 146_ APRPP 151_ GEPPG 156_ SPKSP 161_ GHSTG 166_ SQRPP 171_ DSPGA 176_ PPRSP 181_ SRKKR 186_ RAVGA 191_ KGGGH 196_ TGASA 201_ SAQTG 206_ SPLLP 211_ AASPE 216_ TAKLM 221_ AKAGQ 226_ EELGP 231_ GPAGA 236_ PEPGP 241_ RSPVQ 246_ EDRPG 251_ PGLGL 256_ STPVP 261_ VTEQG 266_ TDQIR 271_ TPRRA 276_ KLHTV 281_ STTVW 286_ EALPD 291_ VSRAK 296_ SDMAV 301_ STPAS 306_ EPQPD 311_ RDMAV 316_ STPAS 321_ EPQSD 326_ RDMAV 331_ STPAS 336_ EPQPD 341_ TDMAV 346_ STPAS 351_ EPQPD 356_ RDMAV 361_ SIPAS 366_ KPQSD 371_ TAVST 376_ PASEP 381_ QSSVA 386_ LSTPI 391_ SKPQL 396_ DTDVA 401_ VSTPA 406_ SKHGL 411_ DVALP 416_ TAGPV 421_ AKLEV 426_ ASSPP 431_ VSEAV 436_ PRMTE 441_ SSGLV 446_ STPVP 451_ RADAA 456_ GLAWP 461_ PTRRA 466_ GPDVV 471_ EMEAV 476_ VSEPS 481_ AGAPG 486_ CCSGA 491_ PALGL 496_ TQVPR 501_ KKKVR 506_ FSVAG 511_ PSPNK 516_ PGSGQ 521_ ASARP 526_ SAPQT 531_ ATGAH 536_ GGPGA 541_ WEAVA 546_ VGPRP 551_ HQPRI 556_ LKHLP 561_ RPPPS 566_ AVTRV 571_ GPGSS 576_ FAVTL 581_ PEAYE 586_ FFFCD 591_ TIEEN 596_ EEAEA 601_ AAAGQ 606_ DPAGV 611_ QWPDM 616_ CEFFF 621_ PDVGA 626_ QRSRR 631_ RGSPE 636_ PLPRA 641_ DPVPA 646_ PIPGD 651_ PVPIS 656_ IPEVY 661_ EHFFF 666_ GEDRL 671_ EGVLG 676_ PAVPL 681_ PLQAL 686_ EPPRS 691_ ASEGA 696_ GPGTP 701_ LKPAV 706_ VERLH 711_ LALRR 716_ AGELR 721_ GPVPS 726_ FAFSQ 731_ NDMCL 736_ VFVAF 741_ ATWAV 746_ RTSDP 751_ HTPDA 756_ WKTAL 761_ LANVG 766_ TISAI 771_ RYFRR 776_ QVGQG 781_RRSHS
1: Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4