Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein)
1_MDALK 6_ SAGRA 11_ LIRSP 16_ SLAKQ 21_ SWGGG 26_ GRHRK 31_ LPENW 36_ TDTRE 41_ TLLEG 46_ MLFSL 51_ KYLGM 56_ TLVEQ 61_ PKGEE 66_ LSAAA 71_ IKRIV 76_ ATAKA 81_ SGKKL 86_ QKVTL 91_ KVSPR 96_ GIILT 101_ DNLTN 106_ QLIEN 111_ VSIYR 116_ ISYCT 121_ ADKMH 126_ DKVFA 131_ YIAQS 136_ QHNQS 141_ LECHA 146_ FLCTK 151_ RKMAQ 156_ AVTLT 161_ VAQAF 166_ KVAFE 171_ FWQVS 176_ KEEKE 181_ KRDKA 186_ SQEGG 191_ DVLGA 196_ RQDCT 201_ PSLKS 206_ LVATG 211_ NLLDL 216_ EETAK 221_ APLST 226_ VSANT 231_ TNMDE 236_ VPRPQ 241_ ALSGS 246_ SVVWE 251_ LDDGL 256_ DEAFS 261_ RLAQS 266_ RTNPQ 271_ VLDTG 276_ LTAQD 281_ MHYAQ 286_ CLSPV 291_ DWDKP 296_ DSSGT 301_EQDDL
1: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity)