KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog)
1_MASER 6_ PEPEV 11_ EEAGQ 16_ VFLLM 21_ KKDYR 26_ ISRNV 31_ RLAWF 36_ LSHLH 41_ QTVQA 46_ TPQEM 51_ LLQSE 56_ QELEV 61_ LSVLP 66_ PGWQP 71_ DEPVV 76_ PRPFL 81_ LVPST 86_ RVTFL 91_ AWQYR 96_ FVIEL 101_ DLSPS 106_ TGIVD 111_ DSTGE 116_ ILFDE 121_ VFHAL 126_ SRCLG 131_ GLLRP 136_ FRVPG 141_ SCIDF 146_ QPEIY 151_ VTIQA 156_ YSSII 161_ GLQSH 166_ QVLVQ 171_ GCLLD 176_ PSQRE 181_ VFLQQ 186_ IYEQL 191_ CLFED 196_ KVATM 201_ LQQQY 206_ DPQSQ 211_ AEDQS 216_ PDSGD 221_ LLGRK 226_ VGVSM 231_ VTADL 236_ GLVSM 241_ IRQGI 246_ LALQL 251_ LPSNS 256_ SAGII 261_ VITDG 266_ VTSVP 271_ DVAVC 276_ ETLLN 281_ QLRSG 286_ TVACS 291_ FVQVG 296_ GVYSY 301_ DCSFG 306_ HVPNV 311_ ELMKF 316_ IAMAT 321_ FGSYL 326_ STCPE 331_ PEPGN 336_ LGLTV 341_ YHRAF 346_ LLYSF 351_ LRSGE 356_ ALNPE 361_ YYCGS 366_ QHRLF 371_ NEHLV 376_ SASSN 381_ PALAL 386_ RRKKH 391_ TEKEV 396_ PADLV 401_ STVSV 406_ RLREG 411_ YSVRE 416_ VTLAK 421_ GGSQL 426_ EVKLV 431_ LLWKH 436_ NMRIE 441_ YVAMA 446_ PWPLE 451_ PEGPR 456_ VTRVE 461_ VTMEG 466_ GYDIL 471_ HDVSC 476_ ALRQP 481_ IRSLY 486_ RTHVI 491_ RRFWN 496_ TLQSI 501_ NQTDQ 506_ MLAHL 511_ QSFSS 516_ VPEHF 521_ TLPDS 526_ TKSGV 531_ PLFYI 536_ PPGST 541_ TPVLS 546_ LQPSG 551_ SDSSH 556_ AQFAA 561_ YWKPV 566_ LSMDA 571_ NSWQR 576_ WLHMH 581_ RLVLI 586_ LEHDT 591_ PIPKH 596_ LHTPG 601_ SNGRY 606_ STIQC 611_ RISHS 616_ SLTSL 621_ LRDWS 626_ SFVLV 631_ EGYSY 636_ VKLLS 641_ SAPDQ 646_ PPNSF 651_ YMVRI 656_ ISKAP 661_ CMVLR 666_ LGFPI 671_ GTPAP 676_ ARHKI 681_ VSGLR 686_ EEILR 691_ LRFPH 696_ RVQSK 701_ EPTPK 706_ VKRKG 711_ LGGAG 716_ GGSSP 721_ SKSPP 726_ VLGPQ 731_ QALSD 736_ RPCLV 741_ VLHKP 746_ LDKLL 751_ IRYEK 756_ LPLDY 761_ RAPFL 766_ LTLEP 771_ PGPLP 776_ LVSGR 781_ SASSS 786_ LASLS 791_ RYLYH 796_ QRWLW 801_ SVPSG 806_ LAPAL 811_ PLSAI 816_ AQLLS 821_ ILTEV 826_ RLSEG 831_ FHFAC 836_ SGEGI 841_ INMVL 846_ ELPIQ 851_ NEPPG 856_ QAAAE 861_ EKHTC 866_ VVQYI 871_ LFPPH 876_ STSTK 881_ DSFST 886_ DDDND 891_ VEVEA 896_ LEGDS 901_ ELNLV 906_ TEVWV 911_ EPQYG 916_ RVGPG 921_ PGIWK 926_ HLQDL 931_ TYSEI 936_ PQALH 941_ PRDAA 946_ CIGSM 951_ LSFEY 956_ LIQLC 961_ QSKEW 966_ GPLPP 971_ EPRVS 976_ DGLDQ 981_ GGDTC 986_ VHEIP 991_ FHFDL 996_ MGLLP 1001_ QCQQL 1006_ QMFFL 1011_ LLARE 1016_ PEGVP 1021_ FAEGS 1026_ CPAND 1031_ MVLCL 1036_ LHSCL 1041_ GQELS 1046_ DREIP 1051_ LTPVD 1056_ QAAFL 1061_ SEVLR 1066_ RTCHV 1071_ PGAEG 1076_ PLLGV 1081_ HGIPK 1086_ EQAVG 1091_ STQAT 1096_ GDSAF 1101_ TSLSV 1106_ GLPET 1111_ LKPLI 1116_ SAQPP 1121_ QWRCY 1126_ ARLVN 1131_ PQHVF 1136_ LTFLP 1141_ ATFSD 1146_ VQRLA 1151_ ACGLE 1156_ GPPQE 1161_ ETKPK 1166_ FGDWS 1171_ GAPSL 1176_ KDLGG 1181_ TGIKA 1186_ TKSHV 1191_ PVLSV 1196_ TLASD 1201_ NAQNQ 1206_ GELSP 1211_ PFRRD 1216_ LQAYA 1221_ GRQAS 1226_ QTESA 1231_ DGPRT 1236_ RCPVY 1241_ IYSCS 1246_ LEALR 1251_ EQMVG 1256_ MQPPQ 1261_ APRDL 1266_ IFRTQ 1271_ FLDHP 1276_ SPSSA 1281_ WMEPR 1286_ YKEAA 1291_ NHCAL 1296_ LQEHA 1301_ QRCYV 1306_ RGLFR 1311_ SLQQA 1316_ QSVTS 1321_ QDLLT 1326_ AVDAC 1331_ EELLQ 1336_ EIDIT 1341_ PFLLA 1346_ LCGHT 1351_ WGLPH 1356_ APPSP 1361_ GPLSP 1366_ GPFSS 1371_ SMEEG 1376_ AEPRE 1381_ RAILA 1386_ SESSI 1391_ ETEDL 1396_ SEPEF 1401_ QSTRV 1406_ PGIPD 1411_ PGPEI 1416_ SLTDV 1421_ CQLRG 1426_ EAHGA 1431_ LHSVI 1436_ QEKFL 1441_ EISRL 1446_ HFRTV 1451_ PSNPH 1456_ YFFYC 1461_ PPSSR 1466_ REDEG 1471_ PRDTV 1476_ DRKIS 1481_ DLEFS 1486_ EAELM 1491_ GEEGD 1496_ TSACC 1501_ VVTES 1506_ DPELE 1511_ VEYRE 1516_ SRESD 1521_ LGPAG 1526_ LDSAS 1531_ LSDVD 1536_ TVNPD 1541_ EDSFS 1546_ ILGGD 1551_ SPTGP 1556_ ESFLH 1561_ DLPPL 1566_ FLHLT 1571_ CSVRL 1576_ RGQHS 1581_ SVPVC 1586_ SLPTC 1591_ LGQVL 1596_ SSLEG 1601_ PPVGG 1606_ RVPLR 1611_ DLSVT 1616_ LDVFM 1621_ LTLPL 1626_ EVELP 1631_ TASDP 1636_ QHHRS 1641_ TSESS 1646_ ASFPR 1651_ SPGQP 1656_ SSLRS 1661_ DDGLG 1666_ PPLPP 1671_ PEEER 1676_ HPGLS 1681_ NLATP 1686_ HRLAI 1691_ ETTMN 1696_ EIRWL 1701_ LEDEM 1706_ VGALR 1711_ RGGIP 1716_ QSPAL 1721_ HRAAA 1726_ HIHSS 1731_ PGRST 1736_ CLRQT 1741_ LPLSF 1746_ VFGPE 1751_ RSLTQ 1756_ FKEEF 1761_ RRLHL 1766_ PGHVL 1771_ LEDPD 1776_ SGFFF 1781_ VAAGQ 1786_ QPGGS 1791_ HGEPS 1796_ SAAWA 1801_ WHSHE 1806_ DRAEG 1811_ IEGET 1816_ LTASP 1821_ QAPGS 1826_ PEDSE 1831_ GVPLI 1836_ SLPRV 1841_ PQGGS 1846_ QPGPS 1851_ RGLSL 1856_ MSSQG 1861_ SVDSD 1866_ HLGYD 1871_ GGSSG 1876_ SDSEG 1881_ PNDTL 1886_ GEKAP 1891_ FTLRT 1896_ PPGPA 1901_ PPQPS 1906_ LSGLP 1911_ GPCLP 1916_ DFWLI 1921_ VRVLQ 1926_ DRVEV 1931_ YAHAR 1936_ SLIRE 1941_ DGGPG 1946_ TECRH 1951_ LQQLL 1956_ VRRVG 1961_ EICRE 1966_ VNQRL 1971_ LLQDL 1976_ HDSHV 1981_ CNSLL 1986_ VAESE 1991_ EDLWR 1996_ SETPF 2001_ HSRQR 2006_ APLPS 2011_ DDYAA 2016_ DESCA 2021_ PRGYL 2026_ AATMQ 2031_ FVPGH 2036_ FSCDV 2041_ VWGTV 2046_ IRVHS 2051_ RLKMG 2056_ PSMGV 2061_ SRAIQ 2066_ ALRSV 2071_ LNAFS 2076_ VVNRK 2081_ NMFVY 2086_ QERAT 2091_ KAVYY 2096_ LRLLE 2101_ TSCSD 2106_ RPWKG 2111_ DALPP 2116_ SLALS 2121_ RSQEP 2126_ IYSEE 2131_ ASGPR 2136_ SPLDM 2141_ VSSRS 2146_ SDAAR 2151_ PVGQV 2156_ DRHIQ 2161_ LLVHG 2166_ VGQAG 2171_ PEITD 2176_ ELVRV 2181_ LCRRL 2186_ DEATL 2191_ DVITV 2196_ MLVRN 2201_ CKLTP 2206_ ADVEF 2211_ IQPPG 2216_ SLPSE 2221_ VLHLA 2226_ LPTSC 2231_ RPWLP 2236_ ALAWY 2241_ LRQNL 2246_ LIFLH 2251_ SPKYT 2256_ DSNSR 2261_ NHFQH 2266_ PLPPQ 2271_ GGLPD 2276_ LDIYL 2281_ YNKPG 2286_ GQGTG 2291_ GKGVA 2296_ CITLA 2301_ FVDEG 2306_ GAPLS 2311_ LALWP 2316_ PSSPG 2321_ PPDPL 2326_ REEEF 2331_ EQLTQ 2336_ VIRCP 2341_ VVVDS 2346_ SSAQN 2351_ GAPRL 2356_ RLDVW 2361_ EKGNI 2366_ SIVQL 2371_ EEKLR 2376_ GAARQ 2381_ ALADA 2386_ IIELQ 2391_ LLPAS 2396_ LCTED 2401_ TPTGS 2406_ LRNGS 2411_ LETKS 2416_ SAGRA 2421_ STFPP 2426_ APVPG 2431_ EPVTP 2436_ PSKAG 2441_ RRSFW 2446_ DMLSK 2451_ TECGD 2456_ LGSPK 2461_ TTDDI 2466_ VLDRP 2471_ EDTRG 2476_ RRRHK 2481_ TESVR 2486_ TPGGA 2491_ ERAPG 2496_ SDSGA 2501_ QRQKR 2506_ RTTQL 2511_ EEGEV 2516_ GTLHP 2521_ VFARV 2526_ AQRWM 2531_ EFMVQ 2536_ IGCAS 2541_ VSRSS 2546_ AHMVS 2551_ RFLLP 2556_ SILSE 2561_ FTALV 2566_ TSMAG 2571_ DTSVR 2576_ IFEQH 2581_ LGSEP 2586_ EIFGP 2591_ CSPGQ 2596_ LGPSP 2601_ RPAAE 2606_ RHLLL 2611_ LGRNF 2616_ LQWRR 2621_ PTQQA 2626_ AKAMQ 2631_ RFEPG 2636_ GDGSS 2641_ GRNAP 2646_ RQRLL 2651_ LLEVV 2656_ DKKLQ 2661_ LLTYN 2666_ WAPDL 2671_ GAALG 2676_ RALVR 2681_ LVQWQ 2686_ NARAH 2691_ LIFCL 2696_ LSQKL 2701_ GLFHH 2706_ YGQLD 2711_ FPVRD 2716_ EKEPN 2721_ PFLLP 2726_ TMEVE 2731_ TLIRS 2736_ ASPPL 2741_ SREQG 2746_ RLSGS 2751_ SRGGG 2756_ PLPLD 2761_ TFPFD 2766_ EALRD 2771_ ITAAR 2776_ PSSVL 2781_ GPVPR 2786_ PPDPV 2791_ TYHGQ 2796_ QFLEI 2801_ KMAER 2806_ RELER 2811_ QMKME 2816_ NLFVT 2821_ WQQRS 2826_ TPATM 2831_ PISAG 2836_ ELETL 2841_ KQSSR 2846_ LVHYC 2851_ ATAML 2856_ FDPAA 2861_ WLHGP 2866_ PETSG 2871_ PPDGQ 2876_ RRHRP 2881_ ESGSG 2886_ SREAP 2891_ TSCES 2896_ LDVSP 2901_ PGARE 2906_ EPWLK 2911_ ELSLA 2916_ FLQQY 2921_ VQYLQ 2926_ SIGFV 2931_ LVPLR 2936_ PPSPA 2941_ RSTSR 2946_ PRAMA 2951_ ILGTE 2956_ GRGSF 2961_ SCPKT 2966_ KTDGS 2971_ PKSTS 2976_ SPVTT 2981_ YHLQR 2986_ ALPGG 2991_ IILME 2996_ LAFQG 3001_ CYFCV 3006_ KQFAL 3011_ ECSRI 3016_ PMGQA 3021_ VNSQL 3026_ SMLFT 3031_ EECDK 3036_ VRDLM 3041_ HVHSF 3046_ SYDFH 3051_ LRLVH 3056_ QHVLG 3061_ AHLVL 3066_ RHGYH 3071_ LTTFL 3076_ RHFLA 3081_ HHPDG 3086_ PHFGR 3091_ NHIYQ 3096_ GTLEL 3101_ PTPLI 3106_ AAHQL 3111_ YNYVA 3116_ DHASS 3121_ YHMKP 3126_ LRMAR 3131_ PGGPE 3136_ HNEYA 3141_ LVSAW 3146_ HSSGS 3151_ YLDSE 3156_ GLRHQ 3161_ DDFDV 3166_ SLLVC 3171_ HCAAP 3176_ FEEQG 3181_ EAERH 3186_ VLRLQ 3191_ FFVVL 3196_ TSQRE 3201_ LFPRL 3206_ TADMR 3211_ RFRKP 3216_ PRLPP 3221_ EPEAP 3226_ GSSAG 3231_ SPGEA 3236_ SGLIL 3241_ APGPA 3246_ PLFPP 3251_ LAAEV 3256_ GMARA 3261_ RLAQL 3266_ VRLAG 3271_ GHCRR 3276_ DTLWK 3281_ RLFLL 3286_ EPPGP 3291_ DRLRL 3296_ GGRLA 3301_ LAELE 3306_ ELLEA 3311_ VHAKS 3316_ IGDID 3321_ PQLDC 3326_ FLSMT 3331_ VSWYQ 3336_ SLIKV 3341_ LLSRF 3346_ PQSCR 3351_ HFQSP 3356_ DLGTQ 3361_ YLVVL 3366_ NQKFT 3371_ DCFVL 3376_ VFLDS 3381_ HLGKT 3386_ SLTVV 3391_ FREPF 3396_ PVQPQ 3401_ DSESP 3406_ PAQLV 3411_ STYHH 3416_ LESVI 3421_ NTACF 3426_TLWTR
1: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity)