Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1)
1_MSWGT 6_ ELWDQ 11_ FDSLD 16_ KHTQW 21_ GIDFL 26_ ERYAK 31_ FVKER 36_ IEIEQ 41_ NYAKQ 46_ LRNLV 51_ KKYCP 56_ KRSSK 61_ DEEPR 66_ FTSCV 71_ AFFNI 76_ LNELN 81_ DYAGQ 86_ REVVA 91_ EEMAH 96_ RVYGE 101_ LMRYA 106_ HDLKT 111_ ERKMH 116_ LQEGR 121_ KAQQY 126_ LDMCW 131_ KQMDN 136_ SKKKF 141_ ERECR 146_ EAEKA 151_ QQSYE 156_ RLDND 161_ TNATK 166_ ADVEK 171_ AKQQL 176_ NLRTH 181_ MADEN 186_ KNEYA 191_ AQLQN 196_ FNGEQ 201_ HKHFY 206_ VVIPQ 211_ IYKQL 216_ QEMDE 221_ RRTIK 226_ LSECY 231_ RGFAD 236_ SERKV 241_ IPIIS 246_ KCLEG 251_ MILAA 256_ KSVDE 261_ RRDSQ 266_ MVVDS 271_ FKSGF 276_ EPPGD 281_ FPFED 286_ YSQHI 291_ YRTIS 296_ DGTIS 301_ ASKQE 306_ SGKMD 311_ AKTTV 316_ GKAKG 321_ KLWLF 326_ GKKPK 331_ PQSPP 336_ LTPTS 341_ LFTSS 346_ TPNGS 351_ QFLTF 356_ SIEPV 361_ HYCMN 366_ EIKTG 371_ KPRIP 376_ SFRSL 381_ KRGWS 386_ VKMGP 391_ ALEDF 396_ SHLPP 401_ EQRRK 406_ KLQQR 411_ IDELN 416_ RELQK 421_ ESDQK 426_ DALNK 431_ MKDVY 436_ EKNPQ 441_ MGDPG 446_ SLQPK 451_ LAETM 456_ NNIDR 461_ LRMEI 466_ HKNEA 471_ WLSEV 476_ EGKTG 481_ GRGDR 486_ RHSSD 491_ INHLV 496_ TQGRE 501_ SPEGS 506_ YTDDA 511_ NQEVR 516_ GPPQQ 521_ HGHHN 526_ EFDDE 531_ FEDDD 536_ PLPAI 541_ GHCKA 546_ IYPFD 551_ GHNEG 556_ TLAMK 561_ EGEVL 566_ YIIEE 571_ DKGDG 576_ WTRAR 581_ RQNGE 586_ EGYVP 591_ TSYID 596_VTLEK
1: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens