Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4)
1_MLRSC 6_ AARLR 11_ TLGAL 16_ CLPPV 21_ GRRLP 26_ GSEPR 31_ PELRS 36_ FSSEE 41_ VILKD 46_ CSVPN 51_ PSWNK 56_ DLRLL 61_ FDQFM 66_ KKCED 71_ GSWKR 76_ LPSYK 81_ RTPTE 86_ WIQDF 91_ KTHFL 96_ DPKLM 101_ KEEQM 106_ SQAQL 111_ FTRSF 116_ DDGLG 121_ FEYVM 126_ FYNDI 131_ EKRMV 136_ CLFQG 141_ GPYLE 146_ GPPGF 151_ IHGGA 156_ IATMI 161_ DATVG 166_ MCAMM 171_ AGGIV 176_ MTANL 181_ NINYK 186_ RPIPL 191_ CSVVM 196_ INSQL 201_ DKVEG 206_ RKFFV 211_ SCNVQ 216_ SVDEK 221_ TLYSE 226_ ATSLF 231_IKLNP
1: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane