Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3)
1_MDPEQ 6_ SVKGT 11_ KKAEG 16_ SPRKR 21_ LTKGE 26_ AIQTS 31_ VSSSV 36_ PYPGS 41_ GTAAT 46_ QESPA 51_ QELLA 56_ PQPFP 61_ GPSSV 66_ LREGS 71_ QEKTG 76_ QQQKP 81_ PKRPP 86_ IEASV 91_ HISQL 96_ PQHPL 101_ TPAFM 106_ SPGKP 111_ EHLLE 116_ GSTWQ 121_ LVDPM 126_ RPGPS 131_ GSFVA 136_ PGLHP 141_ QSQLL 146_ PSHAS 151_ IIPPE 156_ DLPGV 161_ PKVFV 166_ PRPSQ 171_ VSLKP 176_ TEEAH 181_ KKERK 186_ PQKPG 191_ KYICQ 196_ YCSRP 201_ CAKPS 206_ VLQKH 211_ IRSHT 216_ GERPY 221_ PCGPC 226_ GFSFK 231_ TKSNL 236_ YKHRK 241_ SHAHR 246_ IKAGL 251_ ASGMG 256_ GEMYP 261_ HGLEM 266_ ERIPG 271_ EEFEE 276_ PTEGE 281_ STDSE 286_ EETSA 291_ TSGHP 296_ AELSP 301_ RPKQP 306_ LLSSG 311_ LYSSG 316_ SHSSS 321_ HERCS 326_ LSQSS 331_ TAQSL 336_ EDPPP 341_ FVEPS 346_ SEHPL 351_ SHKPE 356_ DTHTI 361_ KQKLA 366_ LRLSE 371_ RKKVI 376_ DEQAF 381_ LSPGS 386_ KGSTE 391_ SGYFS 396_ RSESA 401_ EQQVS 406_ PPNTN 411_ AKSYA 416_ EIIFG 421_ KCGRI 426_ GQRTA 431_ MLTAT 436_ STQPL 441_ LPLST 446_ EDKPS 451_ LVPLS 456_ VPRTQ 461_ VIEHI 466_ TKLIT 471_ INEAV 476_ VDTSE 481_ IDSVK 486_ PRRSS 491_ LSRRS 496_ SMESP 501_ KSSLY 506_ REPLS 511_ SHSEK 516_ TKPEQ 521_ SLLSL 526_ QHPPS 531_ TAPPV 536_ PLLRS 541_ HSMPS 546_ AACTI 551_ STPHH 556_ PFRGS 561_ YSFDD 566_ HITDS 571_ EALSH 576_ SSHVF 581_ TSHPR 586_ MLKRQ 591_ PAIEL 596_ PLGGE 601_ YSSEE 606_ PGPSS 611_ KDTAS 616_ KPSDE 621_ VEPKE 626_ SELTK 631_ KTKKG 636_ LKTKG 641_ VIYEC 646_ NICGA 651_ RYKKR 656_ DNYEA 661_ HKKYY 666_ CSELQ 671_ IAKPI 676_ SAGTH 681_ TSPEA 686_ EKSQI 691_ EHEPW 696_ SQMMH 701_ YKLGT 706_ TLELT 711_ PLRKR 716_ RKEKS 721_ LGDEE 726_ EPPAF 731_ ESTKS 736_ QFGSP 741_ GPSDA 746_ ARNLP 751_ LESTK 756_ SPAEP 761_ SKSVP 766_ SLEGP 771_ TGFQP 776_ RTPKP 781_ GSGSE 786_ SGKER 791_ RTTSK 796_ EISVI 801_ QHTSS 806_ FEKSD 811_ SLEQP 816_ SGLEG 821_ EDKPL 826_ AQFPS 831_ PPPAP 836_ HGRSA 841_ HSLQP 846_ KLVRQ 851_ PNIQV 856_ PEILV 861_ TEEPD 866_ RPDTE 871_ PEPPP 876_ KEPEK 881_ TEEFQ 886_ WPQRS 891_ QTLAQ 896_ LPAEK 901_ LPPKK 906_ KRLRL 911_ AEMAQ 916_ SSGES 921_ SFESS 926_ VPLSR 931_ SPSQE 936_ SNVSL 941_ SGSSR 946_ SASFE 951_ RDDHG 956_ KAEAP 961_ SPSSD 966_ MRPKP 971_ LGTHM 976_ LTVPS 981_ HHPHA 986_ REMRR 991_ SASEQ 996_ SPNVS 1001_ HSAHM 1006_ TETRS 1011_ KSFDY 1016_ GSLSL 1021_ TGPSA 1026_ PAPVA 1031_ PPARV 1036_ APPER 1041_ RKCFL 1046_ VRQAS 1051_ LSRPP 1056_ ESELE 1061_ VAPKG 1066_ RQESE 1071_ EPQPS 1076_ SSKPS 1081_ AKSSL 1086_ SQISS 1091_ AATSH 1096_ GGPPG 1101_ GKGPG 1106_ QDRPP 1111_ LGPTV 1116_ PYTEA 1121_ LQVFH 1126_ HPVAQ 1131_ TPLHE 1136_ KPYLP 1141_ PPVSL 1146_ FSFQH 1151_ LVQHE 1156_ PGQSP 1161_ EFFST 1166_ QAMSS 1171_ LLSSP 1176_ YSMPP 1181_ LPPSL 1186_ FQAPP 1191_ LPLQP 1196_ TVLHP 1201_ GQLHL 1206_ PQLMP 1211_ HPANI 1216_ PFRQP 1221_ PSFLP 1226_ MPYPT 1231_ SSALS 1236_ SGFFL 1241_ PLQSQ 1246_ FALQL 1251_ PGDVE 1256_ SHLPQ 1261_ IKTSL 1266_ APLAT 1271_ GSAGL 1276_ SPSTE 1281_ YSSDI 1286_ RLPPV 1291_ APPAS 1296_ SSAPT 1301_ SAPPL 1306_ ALPAC 1311_ PDTMV 1316_ SLVVP 1321_ VRVQT 1326_ NMPSY 1331_ GSAMY 1336_ TTLSQ 1341_ ILVTQ 1346_ SQGSS 1351_ ATVAL 1356_ PKFEE 1361_ PPSKG 1366_ TTVCG 1371_ ADVHE 1376_ VGPGP 1381_ SGLSE 1386_ EQSRA 1391_ FPTPY 1396_ LRVPV 1401_ TLPER 1406_ KGTSL 1411_ SSESI 1416_ LSLEG 1421_ SSSTA 1426_ GGSKR 1431_ VLSPA 1436_ GSLEL 1441_ TMETQ 1446_ QQKRV 1451_ KEEEA 1456_ SKADE 1461_ KLELV 1466_ KPCSV 1471_ VLTST 1476_ EDGKR 1481_ PEKSH 1486_ LGNQG 1491_ QGRRE 1496_ LEMLS 1501_ SLSSD 1506_ PSDTK 1511_ EIPPL 1516_ PHPAL 1521_ SHGTA 1526_ PGSEA 1531_ LKEYP 1536_ QPSGK 1541_ PHRRG 1546_ LTPLS 1551_ VKKED 1556_ SKEQP 1561_ DLPSL 1566_ APPSS 1571_ LPLSE 1576_ TSSRP 1581_ AKSQE 1586_ GTDSK 1591_ KVLQF 1596_ PSLHT 1601_ TTNVS 1606_ WCYLN 1611_ YIKPN 1616_ HIQHA 1621_ DRRSS 1626_ VYAGW 1631_ CISLY 1636_ NPNLP 1641_ GVSTK 1646_ AALSL 1651_ LRSKQ 1656_ KVSKE 1661_ TYTMA 1666_ TAPHP 1671_ EAGRL 1676_ VPSSS 1681_ RKPRM 1686_ TEVHL 1691_ PSLVS 1696_ PEGQK 1701_ DLARV 1706_ EKEEE 1711_ RRGEP 1716_ EEDAP 1721_ ASQRG 1726_ EPARI 1731_ KIFEG 1736_ GYKSN 1741_ EEYVY 1746_ VRGRG 1751_ RGKYV 1756_ CEECG 1761_ IRCKK 1766_ PSMLK 1771_ KHIRT 1776_ HTDVR 1781_ PYVCK 1786_ HCHFA 1791_ FKTKG 1796_ NLTKH 1801_ MKSKA 1806_ HSKKC 1811_ QETGV 1816_ LEELE 1821_ AEEGT 1826_ SDDLF 1831_ QDSEG 1836_ REGSE 1841_ AVEEH 1846_ QFSDL 1851_ EDSDS 1856_ DSDLD 1861_ EDEDE 1866_ DEEES 1871_ QDELS 1876_ RPSSE 1881_ APPPG 1886_ PPHAL 1891_ RADSS 1896_ PILGP 1901_ QPPDA 1906_ PASGT 1911_ EATRG 1916_ SSVSE 1921_ AERLT 1926_ ASSCS 1931_ MSSQS 1936_ MPGLP 1941_ WLGPA 1946_ PLGSV 1951_ EKDTG 1956_ SALSY 1961_ KPVSP 1966_ RRPWS 1971_ PSKEA 1976_ GSRPP 1981_ LARKH 1986_ SLTKN 1991_ DSSPQ 1996_ RCSPA 2001_ REPQA 2006_ SAPSP 2011_ PGLHV 2016_ DPGRG 2021_ MGALP 2026_ CGSPR 2031_ LQLSP 2036_ LTLCP 2041_ LGREL 2046_ APRAH 2051_ VLSKL 2056_ EGTTD 2061_ PGLPR 2066_ YSPTR 2071_ RWSPG 2076_ QAESP 2081_ PRSAP 2086_ PGKWA 2091_ LAGPG 2096_ SPSAG 2101_ EHGPG 2106_ LGLDP 2111_ RVLFP 2116_ PAPLP 2121_ HKLLS 2126_ RSPET 2131_ CASPW 2136_ QKAES 2141_ RSPSC 2146_ SPGPA 2151_ HPLSS 2156_ RPFSA 2161_ LHDFH 2166_ GHILA 2171_ RTEEN 2176_ IFSHL 2181_ PLHSQ 2186_ HLTRA 2191_ PCPLI 2196_ PIGGI 2201_ QMVQA 2206_ RPGAH 2211_ PTLLP 2216_ GPTAA 2221_ WVSGF 2226_ SGGGS 2231_ DLTGA 2236_ REAQE 2241_ RGRWS 2246_ PTESS 2251_ SASVS 2256_ PVAKV 2261_ SKFTL 2266_ SSELE 2271_ GGDYP 2276_ KERER 2281_ TGGGP 2286_ GRPPD 2291_ WTPHG 2296_ TGAPA 2301_ EPTPT 2306_ HSPCT 2311_ PPDTL 2316_ PRPPQ 2321_ GRRAA 2326_ QSWSP 2331_ RLESP 2336_ RAPTN 2341_ PEPSA 2346_ TPPLD 2351_ RSSSV 2356_ GCLAE 2361_ ASARF 2366_ PARTR 2371_ NLSGE 2376_ PRTRQ 2381_ DSPKP 2386_ SGSGE 2391_ PRAHP 2396_ HQPED 2401_RVPPN
1: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation