Putative methyltransferase C9orf114 (EC 2.1.1.-) (Centromere protein 32) (CENP-32) (Kinetochore-associated protein) (SPOUT domain-containing methyltransferase 1)
1_MAERG 6_ RKRPC 11_ GPGEH 16_ GQRIE 21_ WRKWK 26_ QQKKE 31_ EKKKW 36_ KDLKL 41_ MKKLE 46_ RQRAQ 51_ EEQAK 56_ RLEEE 61_ EAAAE 66_ KEDRG 71_ RPYTL 76_ SVALP 81_ GSILD 86_ NAQSP 91_ ELRTY 96_ LAGQI 101_ ARACA 106_ IFCVD 111_ EIVVF 116_ DEEGQ 121_ DAKTV 126_ EGEFT 131_ GVGKK 136_ GQACV 141_ QLARI 146_ LQYLE 151_ CPQYL 156_ RKAFF 161_ PKHQD 166_ LQFAG 171_ LLNPL 176_ DSPHH 181_ MRQDE 186_ ESEFR 191_ EGIVV 196_ DRPTR 201_ PGHGS 206_ FVNCG 211_ MKKEV 216_ KIDKN 221_ LEPGL 226_ RVTVR 231_ LNQQQ 236_ HPDCK 241_ TYHGK 246_ VVSSQ 251_ DPRTK 256_ AGLYW 261_ GYTVR 266_ LASCL 271_ SAVFA 276_ EAPFQ 281_ DGYDL 286_ TIGTS 291_ ERGSD 296_ VASAQ 301_ LPNFR 306_ HALVV 311_ FGGLQ 316_ GLEAG 321_ ADADP 326_ NLEVA 331_ EPSVL 336_ FDLYV 341_ NTCPG 346_ QGSRT 351_ IRTEE 356_ AILIS 361_ LAALQ 366_ PGLIQ 371_AGARH
1: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N3 position of a uridine in 28S rRNA (PubMed:39671501). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233)