OTU domain-containing protein 3 (EC 3.4.19.12)
1_MSRKQ 6_ AAKSR 11_ PGSGS 16_ RKAEA 21_ ERKRD 26_ ERAAR 31_ RALAK 36_ ERRNR 41_ PESGG 46_ GGGCE 51_ EEFVS 56_ FANQL 61_ QALGL 66_ KLREV 71_ PGDGN 76_ CLFRA 81_ LGDQL 86_ EGHSR 91_ NHLKH 96_ RQETV 101_ DYMIK 106_ QREDF 111_ EPFVE 116_ DDIPF 121_ EKHVA 126_ SLAKP 131_ GTFAG 136_ NDAIV 141_ AFARN 146_ HQLNV 151_ VIHQL 156_ NAPLW 161_ QIRGT 166_ EKSSV 171_ RELHI 176_ AYRYG 181_ EHYDS 186_ VRRIN 191_ DNSEA 196_ PAHLQ 201_ TDFQM 206_ LHQDE 211_ SNKRE 216_ KIKTK 221_ GMDSE 226_ DDLRD 231_ EVEDA 236_ VQKVC 241_ NATGC 246_ SDFNL 251_ IVQNL 256_ EAENY 261_ NIESA 266_ IIAVL 271_ RMNQG 276_ KRNNA 281_ EENLE 286_ PSGRV 291_ LKQCG 296_ PLWEE 301_ GGSGA 306_ RIFGN 311_ QGLNE 316_ GRTEN 321_ NKAQA 326_ SPSEE 331_ NKANK 336_ NQLAK 341_ VTNKQ 346_ RREQQ 351_ WMEKK 356_ KRQEE 361_ RHRHK 366_ ALESR 371_ GSHRD 376_ NNRSE 381_ AEANT 386_ QVTLV 391_KTFAA
1: Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:23827681, PubMed:32011234, PubMed:35675826). Important regulator of energy metabolism (PubMed:35675826). Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation (PubMed:35675826). In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234)