Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
1_MTSTF 6_ NPREC 11_ KLSKQ 16_ EGQNY 21_ GFFLR 26_ IEKDT 31_ EGHLV 36_ RVVEK 41_ CSPAE 46_ KAGLQ 51_ DGDRV 56_ LRING 61_ VFVDK 66_ EEHMQ 71_ VVDLV 76_ RKSGN 81_ SVTLL 86_ VLDGD 91_ SYEKA 96_ VKTRV 101_ DLKEL 106_ GQSQK 111_ EQGLS 116_ DNILS 121_ PVMNG 126_ GVQTW 131_ TQPRL 136_ CYLVK 141_ EGGSY 146_ GFSLK 151_ TVQGK 156_ KGVYM 161_ TDITP 166_ QGVAM 171_ RAGVL 176_ ADDHL 181_ IEVNG 186_ ENVED 191_ ASHEE 196_ VVEKV 201_ KKSGS 206_ RVMFL 211_ LVDKE 216_ TDKRH 221_ VEQKI 226_ QFKRE 231_ TASLK 236_ LLPHQ 241_ PRIVE 246_ MKKGS 251_ NGYGF 256_ YLRAG 261_ SEQKG 266_ QIIKD 271_ IDSGS 276_ PAEEA 281_ GLKNN 286_ DLVVA 291_ VNGES 296_ VETLD 301_ HDSVV 306_ EMIRK 311_ GGDQT 316_ SLLVV 321_ DKETD 326_ NMYRL 331_ AHFSP 336_ FLYYQ 341_ SQELP 346_ NGSVK 351_ EAPAP 356_ TPTSL 361_ EVSSP 366_ PDTTE 371_ EVDHK 376_ PKLCR 381_ LAKGE 386_ NGYGF 391_ HLNAI 396_ RGLPG 401_ SFIKE 406_ VQKGG 411_ PADLA 416_ GLEDE 421_ DVIIE 426_ VNGVN 431_ VLDEP 436_ YEKVV 441_ DRIQS 446_ SGKNV 451_ TLLVC 456_ GKKAY 461_ DYFQA 466_ KKIPI 471_ VSSLA 476_ DPLDT 481_ PPDSK 486_ EGIVV 491_ ESNHD 496_ SHMAK 501_ ERAHS 506_ TASHS 511_SSNSE
1: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity)