Protein O-mannosyl-transferase TMTC4 (EC 2.4.1.109) (Transmembrane and TPR repeat-containing protein 4)
1_MAVLD 6_ TDLDH 11_ ILPSS 16_ VLPPF 21_ WAKLV 26_ VGSVA 31_ IVCFA 36_ RSYDG 41_ DFVFD 46_ DSEAI 51_ VNNKD 56_ LQAET 61_ PLGDL 66_ WHHDF 71_ WGSRL 76_ SSNTS 81_ HKSYR 86_ PLTVL 91_ TFRIN 96_ YYLSG 101_ GFHPV 106_ GFHVV 111_ NILLH 116_ SGISV 121_ LMVDV 126_ FSVLF 131_ GGLQY 136_ TSKGR 141_ RLHLA 146_ PRASL 151_ LAALL 156_ FAVHP 161_ VHTEC 166_ VAGVV 171_ GRADL 176_ LCALF 181_ FLLSF 186_ LGYCK 191_ AFRES 196_ NKEGA 201_ HSSTF 206_ WVLLS 211_ IFLGA 216_ VAMLC 221_ KEQGI 226_ TVLGL 231_ NAVFD 236_ ILVIG 241_ KFNVL 246_ EIVQK 251_ VLHKD 256_ KSLEN 261_ LGMLR 266_ NGGLL 271_ FRMTL 276_ LTSGG 281_ AGMLY 286_ VRWRI 291_ MGTGP 296_ PAFTE 301_ VDNPA 306_ SFADS 311_ MLVRA 316_ VNYNY 321_ YYSLN 326_ AWLLL 331_ CPWWL 336_ CFDWS 341_ MGCIP 346_ LIKSI 351_ SDWRV 356_ IALAA 361_ LWFCL 366_ IGLIC 371_ QALCS 376_ EDGHK 381_ RRILT 386_ LGLGF 391_ LVIPF 396_ LPASN 401_ LFFRV 406_ GFVVA 411_ ERVLY 416_ LPSVG 421_ YCVLL 426_ TFGFG 431_ ALSKH 436_ TKKKK 441_ LIAAV 446_ VLGIL 451_ FINTL 456_ RCVLR 461_ SGEWR 466_ SEEQL 471_ FRSAL 476_ SVCPL 481_ NAKVH 486_ YNIGK 491_ NLADK 496_ GNQTA 501_ AIRYY 506_ REAVR 511_ LNPKY 516_ VHAMN 521_ NLGNI 526_ LKERN 531_ ELQEA 536_ EELLS 541_ LAVQI 546_ QPDFA 551_ AAWMN 556_ LGIVQ 561_ NSLKR 566_ FEAAE 571_ QSYRT 576_ AIKHR 581_ RKYPD 586_ CYYNL 591_ GRLYA 596_ DLNRH 601_ VDALN 606_ AWRNA 611_ TVLKP 616_ EHSLA 621_ WNNMI 626_ ILLDN 631_ TGNLA 636_ QAEAV 641_ GREAL 646_ ELIPN 651_ DHSLM 656_ FSLAN 661_ VLGKS 666_ QKYKE 671_ SEALF 676_ LKAIK 681_ ANPNA 686_ ASYHG 691_ NLAVL 696_ YHRWG 701_ HLDLA 706_ KKHYE 711_ ISLQL 716_ DPTAS 721_ GTKEN 726_ YGLLR 731_ RKLEL 736_MQKKA
1: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3