Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27)
1_MQTSE 6_ REGSG 11_ PELSP 16_ SVMPE 21_ APLES 26_ PPFPT 31_ KSPAF 36_ DLFNL 41_ VLSYK 46_ RLEIY 51_ LEPLK 56_ DAGDG 61_ VRYLL 66_ RWQMP 71_ LCSLL 76_ TCLGL 81_ NVLFL 86_ TLNEG 91_ AWYSV 96_ GALMI 101_ SVPAL 106_ LGYLQ 111_ EVCRA 116_ RLPDS 121_ ELMRR 126_ KYHSV 131_ RQEDL 136_ QRGRL 141_ SRPEA 146_ VAEVK 151_ SFLIQ 156_ LEAFL 161_ SRLCC 166_ TCEAA 171_ YRVLH 176_ WENPV 181_ VSSQF 186_ YGALL 191_ GTVCM 196_ LYLLP 201_ LCWVL 206_ TLLNS 211_ TLFLG 216_ NVEFF 221_ RVVSE 226_ YRASL 231_ QQRMN 236_ PKQEE 241_ HAFES 246_ PPPPD 251_ VGGKD 256_ GLMDS 261_ TPALT 266_ PTEDL 271_ TPGSV 276_ EEAEE 281_ AEPDE 286_ EFKDA 291_ IEETH 296_ LVVLE 301_ DDEGA 306_ PCPAE 311_ DELAL 316_ QDNGF 321_ LSKNE 326_ VLRSK 331_ VSRLT 336_ ERLRK 341_ RYPTN 346_ NFGNC 351_ TGCSA 356_ TFSVL 361_ KKRRS 366_ CSNCG 371_ NSFCS 376_ RCCSF 381_ KVPKS 386_ SMGAT 391_ APEAQ 396_ RETVF 401_ VCASC 406_NQTLS
1: Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701)