Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3)
1_MRAAA 6_ AGGGV 11_ RTAAL 16_ ALLLG 21_ ALHWA 26_ PARCE 31_ EYDYY 36_ GWQAE 41_ PLHGR 46_ SYSKP 51_ PQCLD 56_ IPADL 61_ PLCHT 66_ VGYKR 71_ MRLPN 76_ LLEHE 81_ SLAEV 86_ KQQAS 91_ SWLPL 96_ LAKRC 101_ HSDTQ 106_ VFLCS 111_ LFAPV 116_ CLDRP 121_ IYPCR 126_ SLCEA 131_ VRAGC 136_ APLME 141_ AYGFP 146_ WPEML 151_ HCHKF 156_ PLDND 161_ LCIAV 166_ QFGHL 171_ PATAP 176_ PVTKI 181_ CAQCE 186_ MEHSA 191_ DGLME 196_ QMCSS 201_ DFVVK 206_ MRIKE 211_ IKIEN 216_ GDRKL 221_ IGAQK 226_ KKKLL 231_ KPGPL 236_ KRKDT 241_ KRLVL 246_ HMKNG 251_ AGCPC 256_ PQLDS 261_ LAGSF 266_ LVMGR 271_ KVDGQ 276_ LLLMA 281_ VYRWD 286_ KKNKE 291_ MKFAV 296_ KFMFS 301_ YPCSL 306_ YYPFF 311_YGAAE
1: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina