E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1)
1_MATSG 6_ GEEAA 11_ AAAPA 16_ PGTPA 21_ TGADT 26_ TPGWE 31_ VAVRP 36_ LLSAS 41_ YSAFE 46_ MKELP 51_ QLVAS 56_ VIESE 61_ SEILH 66_ HEKQY 71_ EPFYS 76_ SFVAL 81_ STHYI 86_ TTVCS 91_ LIPRN 96_ QLQSV 101_ AAACK 106_ VLIEF 111_ SLLRL 116_ ENPDE 121_ ACAVS 126_ QKHLI 131_ LLIKG 136_ LCTGC 141_ SRLDR 146_ TEIIT 151_ FTAMM 156_ KSAKL 161_ PQTVK 166_ TLSDV 171_ EDQKE 176_ LASPV 181_ SPELR 186_ QKEVQ 191_ MNFLN 196_ QLTSV 201_ FNPRT 206_ VASQP 211_ ISTQT 216_ LVEGE 221_ NDEQS 226_ STDQA 231_ SAIKT 236_ KNVFI 241_ AQNVA 246_ SLQEL 251_ GGSEK 256_ LLRVC 261_ LNLPY 266_ FLRYI 271_ NRFQD 276_ AVLAN 281_ SFFIM 286_ PATVA 291_ DATAV 296_ RNGFH 301_ SLVID 306_ VTMAL 311_ DTLSL 316_ PVLEP 321_ LNPSR 326_ LQDVT 331_ VLSLS 336_ CLYAG 341_ VSVAT 346_ CMAIL 351_ HVGSA 356_ QQVRT 361_ GSTSS 366_ KEDDY 371_ ESDAA 376_ TIVQK 381_ CLEIY 386_ DMIGQ 391_ AISSS 396_ RRAGG 401_ EHYQN 406_ FQLLG 411_ AWCLL 416_ NSLFL 421_ ILNLS 426_ PTALA 431_ DKGKE 436_ KDPLA 441_ ALRVR 446_ DILSR 451_ TKEGV 456_ GSPKL 461_ GPGKG 466_ HQGFG 471_ VLSVI 476_ LANHA 481_ IKLLT 486_ SLFQD 491_ LQVEA 496_ LHKGW 501_ ETDGP 506_ PAALS 511_ IMAQS 516_ TSIQR 521_ IQRLI 526_ DSVPL 531_ MNLLL 536_ TLLST 541_ SYRKA 546_ CVLQR 551_ QRKGS 556_ MSSDA 561_ SASTD 566_ SNTYY 571_ EDDFS 576_ STEED 581_ SSQDD 586_ DSEPI 591_ LGQWF 596_ EETIS 601_ PSKEK 606_ AAPPP 611_ PPPPP 616_ PLESS 621_ PRVKS 626_ PSKQA 631_ PGEKG 636_ NILAS 641_ RKDPE 646_ LFLGL 651_ ASNIL 656_ NFITS 661_ SMLNS 666_ RNNFI 671_ RNYLS 676_ VSLSE 681_ HHMAT 686_ LASII 691_ KEVDK 696_ DGLKG 701_ SSDEE 706_ FAAAL 711_ YHFNH 716_ SLVTS 721_ DLQSP 726_ NLQNT 731_ LLQQL 736_ GVAPF 741_ SEGPW 746_ PLYIH 751_ PQSLS 756_ VLSRL 761_ LLIWQ 766_ HKASA 771_ QGDPD 776_ VPECL 781_ KVWDR 786_ FLSTM 791_ KQNAL 796_ QGVVP 801_ SETED 806_ LNVEH 811_ LQMLL 816_ LIFHN 821_ FTETG 826_ RRAIL 831_ SLFVQ 836_ IIQEL 841_ SVNMD 846_ AQMRF 851_ VPLIL 856_ ARLLL 861_ IFDYL 866_ LHQYS 871_ KAPVY 876_ LFEQV 881_ QHNLL 886_ SPPFG 891_ WASGS 896_ QDSNS 901_ RRATT 906_ PLYHG 911_ FKEVE 916_ ENWSK 921_ HFSSD 926_ AVPHP 931_ RFYCV 936_ LSPEA 941_ SEDDL 946_ NRLDS 951_ VACDV 956_ LFSKL 961_ VKYDE 966_ LYAAL 971_ TALLA 976_ AGSQL 981_ DTVRR 986_ KENKN 991_ VTALE 996_ ACALQ 1001_ YYFLI 1006_ LWRIL 1011_ GILPP 1016_ SKTYI 1021_ NQLSM 1026_ NSPEM 1031_ SECDI 1036_ LHTLR 1041_ WSSRL 1046_ RISSY 1051_ VNWIK 1056_ DHLIK 1061_ QGMKA 1066_ EHASS 1071_ LLELA 1076_ STTKC 1081_ SSVKY 1086_ DVEIV 1091_ EEYFA 1096_ RQISS 1101_ FCSID 1106_ CTTIL 1111_ QLHEI 1116_ PSLQS 1121_ IYTLD 1126_ AAISK 1131_ VQVSL 1136_ DEHFS 1141_ KMAAE 1146_ TDPHK 1151_ SSEIT 1156_ KNLLP 1161_ ATLQL 1166_ IDTYA 1171_ SFTRA 1176_ YLLQN 1181_ FNEEG 1186_ TTEKP 1191_ SKEKL 1196_ QGFAA 1201_ VLAIG 1206_ SSRCK 1211_ ANTLG 1216_ PTLVQ 1221_ NLPSS 1226_ VQTVC 1231_ ESWNN 1236_ INTNE 1241_ FPNIG 1246_ SWRNA 1251_ FANDT 1256_ IPSES 1261_ YISAV 1266_ QAAHL 1271_ GTLCS 1276_ QSLPL 1281_ AASLK 1286_ HTLLS 1291_ LVRLT 1296_ GDLIV 1301_ WSDEM 1306_ NPPQV 1311_ IRTLL 1316_ PLLLE 1321_ SSTES 1326_ VAEIS 1331_ SNSLE 1336_ RILGP 1341_ AESDE 1346_ FLARV 1351_ YEKLI 1356_ TGCYN 1361_ ILANH 1366_ ADPNS 1371_ GLDES 1376_ ILEEC 1381_ LQYLE 1386_ KQLES 1391_ SQARK 1396_ AMEEF 1401_ FSDSG 1406_ ELVQI 1411_ MMATA 1416_ NENLS 1421_ AKFCN 1426_ RVLKF 1431_ FTKLF 1436_ QLTEK 1441_ SPNPS 1446_ LLHLC 1451_ GSLAQ 1456_ LACVE 1461_ PVRLQ 1466_ AWLTR 1471_ MTTSP 1476_ PKDSD 1481_ QLDVI 1486_ QENRQ 1491_ LLQLL 1496_ TTYIV 1501_ RENSQ 1506_ VGEGV 1511_ CAVLL 1516_ GTLTP 1521_ MATEM 1526_ LANGD 1531_ GTGFP 1536_ ELMVV 1541_ MATLA 1546_ SAGQG 1551_ AGHLQ 1556_ LHNAA 1561_ VDWLS 1566_ RCKKY 1571_ LSQKN 1576_ VVEKL 1581_ NANVM 1586_ HGKHV 1591_ MILEC 1596_ TCHIM 1601_ SYLAD 1606_ VTNAL 1611_ SQSNG 1616_ QGPSH 1621_ LSVDG 1626_ EERAI 1631_ EVDSD 1636_ WVEEL 1641_ AVEEE 1646_ DSQAE 1651_ DSDED 1656_ SLCNK 1661_ LCTFT 1666_ ITQKE 1671_ FMNQH 1676_ WYHCH 1681_ TCKMV 1686_ DGVGV 1691_ CTVCA 1696_ KVCHK 1701_ DHEIS 1706_ YAKYG 1711_ SFFCD 1716_ CGAKE 1721_ DGSCL 1726_ ALVKR 1731_ TPSSG 1736_ MSSTM 1741_ KESAF 1746_ QSEPR 1751_ ISESL 1756_ VRHAS 1761_ TSSPA 1766_ DKAKV 1771_ TISDG 1776_ KVADE 1781_ EKPKK 1786_ SSLCR 1791_ TVEGC 1796_ REELQ 1801_ NQANF 1806_ SFAPL 1811_ VLDML 1816_ NFLMD 1821_ AIQTN 1826_ FQQAS 1831_ AVGSS 1836_ SRAQQ 1841_ ALSEL 1846_ HTVEK 1851_ AVEMT 1856_ DQLMV 1861_ PTLGS 1866_ QEGAF 1871_ ENVRM 1876_ NYSGD 1881_ QGQTI 1886_ RQLIS 1891_ AHVLR 1896_ RVAMC 1901_ VLSSP 1906_ HGRRQ 1911_ HLAVS 1916_ HEKGK 1921_ ITVLQ 1926_ LSALL 1931_ KQADS 1936_ SKRKL 1941_ TLTRL 1946_ ASAPV 1951_ PFTVL 1956_ SLTGN 1961_ PCKED 1966_ YLAVC 1971_ GLKDC 1976_ HVLTF 1981_ SSSGS 1986_ VSDHL 1991_ VLHPQ 1996_ LATGN 2001_ FIIKA 2006_ VWLPG 2011_ SQTEL 2016_ AIVTA 2021_ DFVKI 2026_ YDLCV 2031_ DALSP 2036_ TFYFL 2041_ LPSSK 2046_ IRDVT 2051_ FLFNE 2056_ EGKNI 2061_ IVIMS 2066_ SAGYI 2071_ YTQLM 2076_ EEASS 2081_ AQQGP 2086_ FYVTN 2091_ VLEIN 2096_ HEDLK 2101_ DSNSQ 2106_ VAGGG 2111_ VSVYY 2116_ SHVLQ 2121_ MLFFS 2126_ YCQGK 2131_ SFAAT 2136_ ISRTT 2141_ LEVLQ 2146_ LFPIN 2151_ IKSSN 2156_ GGSKT 2161_ SPALC 2166_ QWSEV 2171_ MNHPG 2176_ LVCCV 2181_ QQTTG 2186_ VPLVV 2191_ MVKPD 2196_ TFLIQ 2201_ EIKTL 2206_ PAKAK 2211_ IQDMV 2216_ AIRHT 2221_ ACNEQ 2226_ QRTTM 2231_ ILLCE 2236_ DGSLR 2241_ IYMAN 2246_ VENTS 2251_ YWLQP 2256_ SLQPS 2261_ SVISI 2266_ MKPVR 2271_ KRKTA 2276_ TITTR 2281_ TSSQV 2286_ TFPID 2291_ FFEHN 2296_ QQLTD 2301_ VEFGG 2306_ NDLLQ 2311_ VYNAQ 2316_ QIKHR 2321_ LNSTG 2326_ MYVAN 2331_ TKPGG 2336_ FTIEI 2341_ SNNNS 2346_ TMVMT 2351_ GMRIQ 2356_ IGTQA 2361_ IERAP 2366_ SYIEI 2371_ FGRTM 2376_ QLNLS 2381_ RSRWF 2386_ DFPFT 2391_ REEAL 2396_ QADKK 2401_ LNLFI 2406_ GASVD 2411_ PAGVT 2416_ MIDAV 2421_ KIYGK 2426_ TKEQF 2431_ GWPDE 2436_ PPEEF 2441_ PSASV 2446_ SNICP 2451_ SNLNQ 2456_ SNGTG 2461_ DSDSA 2466_ APTTT 2471_ SGTVL 2476_ ERLVV 2481_ SSLEA 2486_ LESCF 2491_ AVGPI 2496_ IEKER 2501_ NKNAA 2506_ QELAT 2511_ LLLSL 2516_ PAPAS 2521_ VQQQS 2526_ KSLLA 2531_ SLHTS 2536_ RSAYH 2541_ SHKDQ 2546_ ALLSK 2551_ AVQCL 2556_ NTSSK 2561_ EGKDL 2566_ DPEVF 2571_ QRLVI 2576_ TARSI 2581_ AIMRP 2586_ NNLVH 2591_ FTESK 2596_ LPQME 2601_ TEGMD 2606_ EGKEP 2611_ QKQLE 2616_ GDCCS 2621_ FITQL 2626_ VNHFW 2631_ KLHAS 2636_ KPKNA 2641_ FLAPA 2646_ CLPGL 2651_ THIEA 2656_ TVNAL 2661_ VDIIH 2666_ GYCTC 2671_ ELDCI 2676_ NTASK 2681_ IYMQM 2686_ LLCPD 2691_ PAVSF 2696_ SCKQA 2701_ LIRVL 2706_ RPRNK 2711_ RRHVT 2716_ LPSSP 2721_ RSNTP 2726_ MGDKD 2731_ DDDDD 2736_ DADEK 2741_ MQSSG 2746_ IPNGG 2751_ HIRQE 2756_ SQEQS 2761_ EVDHG 2766_ DFEMV 2771_ SESMV 2776_ LETAE 2781_ NVNNG 2786_ NPSPL 2791_ EALLA 2796_ GAEGF 2801_ PPMLD 2806_ IPPDA 2811_ DDETM 2816_ VELAI 2821_ ALSLQ 2826_ QDQQG 2831_ SSSSA 2836_ LGLQS 2841_ LGLSG 2846_ QAPSS 2851_ SSLDA 2856_ GTLSD 2861_ TTASA 2866_ PASDD 2871_ EGSTA 2876_ ATDGS 2881_ TLRTS 2886_ PADHG 2891_ GSVGS 2896_ ESGGS 2901_ AVDSV 2906_ AGEHS 2911_ VSGRS 2916_ SAYGD 2921_ ATAEG 2926_ HPAGP 2931_ GSVSS 2936_ STGAI 2941_ STTTG 2946_ HQEGD 2951_ GSEGE 2956_ GEGET 2961_ EGDVH 2966_ TSNRL 2971_ HMVRL 2976_ MLLER 2981_ LLQTL 2986_ PQLRN 2991_ VGGVR 2996_ AIPYM 3001_ QVILM 3006_ LTTDL 3011_ DGEDE 3016_ KDKGA 3021_ LDNLL 3026_ SQLIA 3031_ ELGMD 3036_ KKDVS 3041_ KKNER 3046_ SALNE 3051_ VHLVV 3056_ MRLLS 3061_ VFMSR 3066_ TKSGS 3071_ KSSIC 3076_ ESSSL 3081_ ISSAT 3086_ AAALL 3091_ SSGAV 3096_ DYCLH 3101_ VLKSL 3106_ LEYWK 3111_ SQQND 3116_ EEPVA 3121_ TSQLL 3126_ KPHTT 3131_ SSPPD 3136_ MSPFF 3141_ LRQYV 3146_ KGHAA 3151_ DVFEA 3156_ YTQLL 3161_ TEMVL 3166_ RLPYQ 3171_ IKKIT 3176_ DTNSR 3181_ IPPPV 3186_ FDHSW 3191_ FYFLS 3196_ EYLMI 3201_ QQTPF 3206_ VRRQV 3211_ RKLLL 3216_ FICGS 3221_ KEKYR 3226_ QLRDL 3231_ HTLDS 3236_ HVRGI 3241_ KKLLE 3246_ EQGIF 3251_ LRASV 3256_ VTASS 3261_ GSALQ 3266_ YDTLI 3271_ SLMEH 3276_ LKACA 3281_ EIAAQ 3286_ RTINW 3291_ QKFCI 3296_ KDDSV 3301_ LYFLL 3306_ QVSFL 3311_ VDEGV 3316_ SPVLL 3321_ QLLSC 3326_ ALCGS 3331_ KVLAA 3336_ LAASS 3341_ GSSSA 3346_ SSSSA 3351_ PVAAS 3356_ SGQAT 3361_ TQSKS 3366_ STKKS 3371_ KKEEK 3376_ EKEKD 3381_ GETSG 3386_ SQEDQ 3391_ LCTAL 3396_ VNQLN 3401_ KFADK 3406_ ETLIQ 3411_ FLRCF 3416_ LLESN 3421_ SSSVR 3426_ WQAHC 3431_ LTLHI 3436_ YRNSS 3441_ KSQQE 3446_ LLLDL 3451_ MWSIW 3456_ PELPA 3461_ YGRKA 3466_ AQFVD 3471_ LLGYF 3476_ SLKTP 3481_ QTEKK 3486_ LKEYS 3491_ QKAVE 3496_ ILRTQ 3501_ NHILT 3506_ NHPNS 3511_ NIYNT 3516_ LSGLV 3521_ EFDGY 3526_ YLESD 3531_ PCLVC 3536_ NNPEV 3541_ PFCYI 3546_ KLSSI 3551_ KVDTR 3556_ YTTTQ 3561_ QVVKL 3566_ IGSHT 3571_ ISKVT 3576_ VKIGD 3581_ LKRTK 3586_ MVRTI 3591_ NLYYN 3596_ NRTVQ 3601_ AIVEL 3606_ KNKPA 3611_ RWHKA 3616_ KKVQL 3621_ TPGQT 3626_ EVKID 3631_ LPLPI 3636_ VASNL 3641_ MIEFA 3646_ DFYEN 3651_ YQAST 3656_ ETLQC 3661_ PRCSA 3666_ SVPAN 3671_ PGVCG 3676_ NCGEN 3681_ VYQCH 3686_ KCRSI 3691_ NYDEK 3696_ DPFLC 3701_ NACGF 3706_ CKYAR 3711_ FDFML 3716_ YAKPC 3721_ CAVDP 3726_ IENEE 3731_ DRKKA 3736_ VSNIN 3741_ TLLDK 3746_ ADRVY 3751_ HQLMG 3756_ HRPQL 3761_ ENLLC 3766_ KVNEA 3771_ APEKP 3776_ QDDSG 3781_ TAGGI 3786_ SSTSA 3791_ SVNRY 3796_ ILQLA 3801_ QEYCG 3806_ DCKNS 3811_ FDELS 3816_ KIIQK 3821_ VFASR 3826_ KELLE 3831_ YDLQQ 3836_ REAAT 3841_ KSSRT 3846_ SVQPT 3851_ FTASQ 3856_ YRALS 3861_ VLGCG 3866_ HTSST 3871_ KCYGC 3876_ ASAVT 3881_ EHCIT 3886_ LLRAL 3891_ ATNPA 3896_ LRHIL 3901_ VSQGL 3906_ IRELF 3911_ DYNLR 3916_ RGAAA 3921_ MREEV 3926_ RQLMC 3931_ LLTRD 3936_ NPEAT 3941_ QQMND 3946_ LIIGK 3951_ VSTAL 3956_ KGHWA 3961_ NPDLA 3966_ SSLQY 3971_ EMLLL 3976_ TDSIS 3981_ KEDSC 3986_ WELRL 3991_ RCALS 3996_ LFLMA 4001_ VNIKT 4006_ PVVVE 4011_ NITLM 4016_ CLRIL 4021_ QKLIK 4026_ PPAPT 4031_ SKKNK 4036_ DVPVE 4041_ ALTTV 4046_ KPYCN 4051_ EIHAQ 4056_ AQLWL 4061_ KRDPK 4066_ ASYDA 4071_ WKKCL 4076_ PIRGI 4081_ DGNGK 4086_ APSKS 4091_ ELRHL 4096_ YLTEK 4101_ YVWRW 4106_ KQFLS 4111_ RRGKR 4116_ TSPLD 4121_ LKLGH 4126_ NNWLR 4131_ QVLFT 4136_ PATQA 4141_ ARQAA 4146_ CTIVE 4151_ ALATI 4156_ PSRKQ 4161_ QVLDL 4166_ LTSYL 4171_ DELSI 4176_ AGECA 4181_ AEYLA 4186_ LYQKL 4191_ ITSAH 4196_ WKVYL 4201_ AARGV 4206_ LPYVG 4211_ NLITK 4216_ EIARL 4221_ LALEE 4226_ ATLST 4231_ DLQQG 4236_ YALKS 4241_ LTGLL 4246_ SSFVE 4251_ VESIK 4256_ RHFKS 4261_ RLVGT 4266_ VLNGY 4271_ LCLRK 4276_ LVVQR 4281_ TKLID 4286_ ETQDM 4291_ LLEML 4296_ EDMTT 4301_ GTESE 4306_ TKAFM 4311_ AVCIE 4316_ TAKRY 4321_ NLDDY 4326_ RTPVF 4331_ IFERL 4336_ CSIIY 4341_ PEENE 4346_ VTEFF 4351_ VTLEK 4356_ DPQQE 4361_ DFLQG 4366_ RMPGN 4371_ PYSSN 4376_ EPGIG 4381_ PLMRD 4386_ IKNKI 4391_ CQDCD 4396_ LVALL 4401_ EDDSG 4406_ MELLV 4411_ NNKII 4416_ SLDLP 4421_ VAEVY 4426_ KKVWC 4431_ TTNEG 4436_ EPMRI 4441_ VYRMR 4446_ GLLGD 4451_ ATEEF 4456_ IESLD 4461_ STTDE 4466_ EEDEE 4471_ EVYKM 4476_ AGVMA 4481_ QCGGL 4486_ ECMLN 4491_ RLAGI 4496_ RDFKQ 4501_ GRHLL 4506_ TVLLK 4511_ LFSYC 4516_ VKVKV 4521_ NRQQL 4526_ VKLEM 4531_ NTLNV 4536_ MLGTL 4541_ NLALV 4546_ AEQES 4551_ KDSGG 4556_ AAVAE 4561_ QVLSI 4566_ MEIIL 4571_ DESNA 4576_ EPLSE 4581_ DKGNL 4586_ LLTGD 4591_ KDQLV 4596_ MLLDQ 4601_ INSTF 4606_ VRSNP 4611_ SVLQG 4616_ LLRII 4621_ PYLSF 4626_ GEVEK 4631_ MQILV 4636_ ERFKP 4641_ YCNFD 4646_ KYDED 4651_ HSGDD 4656_ KVFLD 4661_ CFCKI 4666_ AAGIK 4671_ NNSNG 4676_ HQLKD 4681_ LILQK 4686_ GITQN 4691_ ALDYM 4696_ KKHIP 4701_ SAKNL 4706_ DADIW 4711_ KKFLS 4716_ RPALP 4721_ FILRL 4726_ LRGLA 4731_ IQHPG 4736_ TQVLI 4741_ GTDSI 4746_ PNLHK 4751_ LEQVS 4756_ SDEGI 4761_ GTLAE 4766_ NLLEA 4771_ LREHP 4776_ DVNKK 4781_ IDAAR 4786_ RETRA 4791_ EKKRM 4796_ AMAMR 4801_ QKALG 4806_ TLGMT 4811_ TNEKG 4816_ QVVTK 4821_ TALLK 4826_ QMEEL 4831_ IEEPG 4836_ LTCCI 4841_ CREGY 4846_ KFQPT 4851_ KVLGI 4856_ YTFTK 4861_ RVALE 4866_ EMENK 4871_ PRKQQ 4876_ GYSTV 4881_ SHFNI 4886_ VHYDC 4891_ HLAAV 4896_ RLARG 4901_ REEWE 4906_ SAALQ 4911_ NANTK 4916_ CNGLL 4921_ PVWGP 4926_ HVPES 4931_ AFATC 4936_ LARHN 4941_ TYLQE 4946_ CTGQR 4951_ EPTYQ 4956_ LNIHD 4961_ IKLLF 4966_ LRFAM 4971_ EQSFS 4976_ ADTGG 4981_ GGRES 4986_ NIHLI 4991_ PYIIH 4996_ TVLYV 5001_ LNTTR 5006_ ATSRE 5011_ EKNLQ 5016_ GFLEQ 5021_ PKEKW 5026_ VESAF 5031_ EVDGP 5036_ YYFTV 5041_ LALHI 5046_ LPPEQ 5051_ WRATR 5056_ VEILR 5061_ RLLVT 5066_ SQARA 5071_ VAPGG 5076_ ATRLT 5081_ DKAVK 5086_ DYSAY 5091_ RSSLL 5096_ FWALV 5101_ DLIYN 5106_ MFKKV 5111_ PTSNT 5116_ EGGWS 5121_ CSLAE 5126_ YIRHN 5131_ DMPIY 5136_ EAADK 5141_ ALKTF 5146_ QEEFM 5151_ PVETF 5156_ SEFLD 5161_ VAGLL 5166_ SEITD 5171_ PESFL 5176_KDLLN
1: E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886)